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R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases

Departamento de Biología Molecular and Centro Biología Molecular “Severo Ochoa”, Universidad Autónoma de Madrid, 28049 Madrid, Spain
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Int. J. Mol. Sci. 2020, 21(16), 5911; https://doi.org/10.3390/ijms21165911
Received: 23 July 2020 / Revised: 13 August 2020 / Accepted: 14 August 2020 / Published: 17 August 2020
(This article belongs to the Special Issue Cell Signaling in Neurodegeneration)
Myelination is required for fast and efficient synaptic transmission in vertebrates. In the central nervous system, oligodendrocytes are responsible for creating myelin sheaths that isolate and protect axons, even throughout adulthood. However, when myelin is lost, the failure of remyelination mechanisms can cause neurodegenerative myelin-associated pathologies. From oligodendrocyte progenitor cells to mature myelinating oligodendrocytes, myelination is a highly complex process that involves many elements of cellular signaling, yet many of the mechanisms that coordinate it, remain unknown. In this review, we will focus on the three major pathways involved in myelination (PI3K/Akt/mTOR, ERK1/2-MAPK, and Wnt/β-catenin) and recent advances describing the crosstalk elements which help to regulate them. In addition, we will review the tight relation between Ras GTPases and myelination processes and discuss its potential as novel elements of crosstalk between the pathways. A better understanding of the crosstalk elements orchestrating myelination mechanisms is essential to identify new potential targets to mitigate neurodegeneration. View Full-Text
Keywords: myelin; oligodendrocyte; neurodegeneration; PI3K/Akt/mTOR; ERK1/2-MAPK; Wnt/β-catenin; R-Ras myelin; oligodendrocyte; neurodegeneration; PI3K/Akt/mTOR; ERK1/2-MAPK; Wnt/β-catenin; R-Ras
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MDPI and ACS Style

Alcover-Sanchez, B.; Garcia-Martin, G.; Wandosell, F.; Cubelos, B. R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases. Int. J. Mol. Sci. 2020, 21, 5911.

AMA Style

Alcover-Sanchez B, Garcia-Martin G, Wandosell F, Cubelos B. R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases. International Journal of Molecular Sciences. 2020; 21(16):5911.

Chicago/Turabian Style

Alcover-Sanchez, Berta; Garcia-Martin, Gonzalo; Wandosell, Francisco; Cubelos, Beatriz. 2020. "R-Ras GTPases Signaling Role in Myelin Neurodegenerative Diseases" Int. J. Mol. Sci. 21, no. 16: 5911.

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