Targeted Protection of Mitochondrial Functions by Bioactive Natural Products
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 4589
Special Issue Editor
Interests: natural products; inflammation; signal transduction; transcription factors; gene expression; antitumor therapy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The focus of this Topical Collection is to investigate the mechanism(s) of action of natural molecules targeting mitochondria and being effective in preventing or counteracting human diseases.
Mitochondria functionalities are very important to maintain energy homeostasis, cellular metabolism, and to control cell stress responses. Mitochondria are the main intracellular source of reactive oxygen species and are very dynamic organelles because they respond to insults by fission or fusion, induce autophagy or apoptosis, and finally control cell life or death. Therefore, mitochondria fulfill great relevance in biomedicine. Indeed, their activity dysregulation results in pathological processes like inflammation, aging, carcinogenesis, and neurodegeneration.
In this scenario, many natural compounds are active in affecting specific mitochondrial enzymes, and in modulating the signaling from or to mitochondria. Thus, the mitochondrion represents an emerging target for molecules deriving from natural sources that can open in turn new therapeutic perspectives for the prevention and cure of metabolic disorders and other human diseases.
We welcome here submissions of studies on the effects of natural compounds on mitochondria and on their nutritional applications using molecular biology, as well as biochemical, cellular, and immunological methods.
Importantly, the exact active ingredient of a vegetable extract must be reported in the submitted research manuscript, since papers describing effects of mixed extraction from plants are not accepted.
Prof. Dr. Marta Menegazzi
Collection Editor
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Keywords
- natural products
- mitochondrial function
- mitochondrial dynamic
- metabolism
- energy homeostasis
- ROS
- inflammation
- cancer
- neurodegeneration
- aging, apoptosis
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