Ribonucleases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: 30 June 2024 | Viewed by 241
Special Issue Editors
Interests: natural products; inflammation; signal transduction; transcription factors; gene expression; antitumor therapy
Special Issues, Collections and Topics in MDPI journals
Interests: investigations of protein structure and function and oligomerization; pancreatic-type Ribonucleases (RNase A, BS-RNase, Onconase) covalent or non-covalent oligomerization through 3D domain swapping; antitumor activity of covalent or domain-swapped RNase oligomers, in vitro and in mice; studies of the mechanism(s) of RNases oligomerization; investigations on the in vitro alpha-synuclein aggregation
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Our proposed Special Issue aims to collect research related to the structural and/or functional properties of ribonucleases (RNases). The world of RNases is vast, extensive, and difficult to confine within a specific domain. Nevertheless, our goal is to include contributions such as articles or reviews that highlight biochemical aspects directly associated with the structure–function relationship and/or the roles of RNases or proteins found to exhibit ribonucleolytic activity.
The RNases to which we refer can be listed as the secretory pancreatic-type RNases, such as RNase 1–8, which include examples like RNase A, ECP, EDN, and angiogenin. Additionally, there are bacterial RNases, like barnase or binase, as well as endo-RNases, like RNase H, RNase L, RNase J, RNase P, RNase III, Dicer, etc.
These RNases can act on a variety of targets, including single-stranded RNAs (ssRNAs), double-stranded RNAs (dsRNAs), DNA:RNA hybrids, viral RNAs, mRNAs, tRNAs, and non-coding RNAs.
Contributions that describe the potential antiviral, antibacterial, antitumoral, and/or other biological effects of these enzymes, whether in vitro or in vivo, are of particular interest and add value to the submissions of other authors.
We would like to emphasize that manuscripts only reporting theoretical or proteomic analyses without supporting experimental evidence will not be considered.
Dr. Marta Menegazzi
Dr. Giovanni Gotte
Guest Editors
Manuscript Submission Information
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Keywords
- ribonucleases
- structure–function relationship
- antitumor activity
- antibacterial activity
- antiviral activity
