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Ozone Therapy in Cancer Treatment
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Ozone Therapy in Cancer Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 3193

Special Issue Editors

Prof. Dr. Francisco Rodríguez-Esparragón

E-Mail Website
Guest Editor
1. Research Unit, Hospital Universitario de Gran Canaria Dr. Negrín, 35019 Las Palmas de Gran Canaria, Spain
2. Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), 35019 Las Palmas de Gran Canaria, Spain
3. Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 La Laguna, Spain
4. CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, 28029 Madrid, Spain
Interests: ozone therapy; atherosclerosis; hypertension; lipoproteins; genomics
Dr. Bernadino Clavo

E-Mail Website
Guest Editor
1. Research Unit, Chronic Pain Unit and Radiation Oncology, Dr. Negrín University Hospital, 35019 Las Palmas, Spain
2. Fundación Canaria del Instituto de Investigación Sanitaria de Canarias (FIISC), 35019 Las Palmas, Spain
3. Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, 38296 La Laguna, Spain
4. CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain
5. Universitary Institute for Research in Biomedicine and Health (IUIBS), Molecular and Translational Pharmacology (BIOPHARM) Group, University of Las Palmas de Gran Canaria, 35016 Las Palmas, Spain
Interests: preclinical and clinical research (ozone therapy, oxidative stress modulation, side-effects of cancer treatment, oncology, radiation therapy, chronic pain)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ozone therapy is increasingly applied all over the world; however, despite the wide scientific evidence supporting the therapeutic potential of ozone treatment, the mechanistic explanation for its positive effects is still incomplete.

This Special Issue aims at illustrating established and novel knowledge on the cellular and molecular mechanisms accounting for the observed effect of ozone therapy and its clinical implications for different aspects of cancer treatment, such as the enhancement of chemotherapy or radiotherapy, or the potential effect in the prevention or treatment of several chemotherapy- or radiation-induced side effects, among others.

We invite researchers from all fields—physicians, pharmacologists, biologists, chemists, etc.—to present their results and propose prospective clinical applications by contributing short reports, original research articles, or review papers. Manuscripts may deal with the findings obtained on patients or animal models in vivo as well as on tissues and cells in vitro.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process

Prof. Dr. Francisco Rodríguez-Esparragón
Dr. Bernadino Clavo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidant responses
  • oxidative stress
  • gene expression
  • immune response
  • inflammation
  • mitochondrial activity
  • ozone therapy
  • cancer treatment
  • side effects
  • radiotherapy
  • chemotherapy

Published Papers (1 paper)

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Review

25 pages, 440 KiB  
Review
Ozone in Chemotherapy-Induced Peripheral Neuropathy—Current State of Art, Possibilities, and Perspectives
by Katarzyna Szklener, Anna Rudzińska, Pola Juchaniuk, Zuzanna Kabała and Sławomir Mańdziuk
Int. J. Mol. Sci. 2023, 24(6), 5279; https://doi.org/10.3390/ijms24065279 - 09 Mar 2023
Cited by 3 | Viewed by 2647
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most detrimental toxicity to a patient’s quality of life. Pathophysiological mechanisms involved in CIPN pathogenesis are complex, multifactorial, and only partially examined. They are suspected to be associated with oxidative stress (OS), mitochondrial dysfunction, ROS-induced [...] Read more.
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most detrimental toxicity to a patient’s quality of life. Pathophysiological mechanisms involved in CIPN pathogenesis are complex, multifactorial, and only partially examined. They are suspected to be associated with oxidative stress (OS), mitochondrial dysfunction, ROS-induced apoptosis, myelin sheath and DNA damage, and immunological and inflammatory processes. Unfortunately, medications commonly used for the management of other neuropathic pain syndromes, including gabapentinoids, opioids, and tricyclic antidepressants (such as desipramine and nortriptyline), do not bring satisfactory results in CIPN. The aim of this review is to evaluate the existing literature on the potential use of medical ozone as a treatment for CIPN. This paper would explore the potential therapeutic benefits of medical ozone. The review would evaluate the existing literature on the use of medical ozone in other contexts, as well as its potential application in treating CIPN. The review would also suggest possible research methods, such as randomized controlled trials, to evaluate the efficacy of medical ozone as a treatment for CIPN. Medical ozone has been used to disinfect and treat diseases for over 150 years. The effectiveness of ozone in treating infections, wounds, and a variety of diseases has been well documented. Ozone therapy is also documented to inhibit the growth of human cancer cells and has antioxidative and anti-inflammatory effects. Due to its ability to modulate oxidative stress, inflammation, and ischemia/hypoxia, ozone may have a potentially valuable effect on CIPN. Full article
(This article belongs to the Special Issue Ozone Therapy in Cancer Treatment)
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