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Polyphenols and Their Transformation Products: Properties and Mechanism of Action

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 5026

Special Issue Editors


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Guest Editor
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, 142290 Pushchino, Russia
Interests: natural compounds; cell death; oxidative stress; natural compound analogs; structure-activity relationship

E-Mail Website
Guest Editor
Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia
Interests: mitochondria; biophysics; diabetes mellitus; myopathy; mitochondrial Ca2+ transport; permeability transition pore; oxidative stress; reactive oxygen species; lipids; membrane proteins; liposomes
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Special Issue Information

Dear Colleagues,

Polyphenols are secondary metabolites in plants. These compounds are found in plant-based foods and beverages and are an integral part of our diet. The consumption of polyphenols or their sources may be associated with a reduced risk of a number of diseases, including cardiovascular, neurodegenerative and other diseases. These compounds exhibit a variety of biological activities, including antioxidant, anti-inflammatory, antidiabetic, antibacterial and anticarcinogenic activities. During the storage, processing and digestion, polyphenols undergo various modifications. In particular, they interact with compounds present in food, are metabolized by the microbiota of the gastrointestinal tract and/or transform inside the cells. As a result, a wide range of transformation products of polyphenols are formed. The properties of these compounds and their impact on health remain largely unknown.

This Special Issue focuses on the mechanisms underlying the effects of polyphenols on human health, with special attention to their transformation products. We welcome comprehensive reviews and original research papers.

Potential topics include, but are not limited to:

  • Transformation products of polyphenols formed in real foods and in vivo;
  • Properties of polyphenols and their transformation products;
  • Biological activity of polyphenols and their products;
  • Potential cytotoxic effects of these compounds;
  • Mechanisms underlying the effects of polyphenols and their products;
  • Future perspective of these compounds in medicine.

Dr. Yuri Shatalin
Prof. Dr. Konstantin Belosludtsev
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

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Keywords

  • polyphenols
  • transformation products
  • Biological activity
  • cytotoxic effects
  • mechanism of action
  • health effect

Published Papers (4 papers)

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Research

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14 pages, 3239 KiB  
Article
Comparative Analysis of Fluorescence Emission in Myricetin, Kaempferol, and Quercetin Powders and Solutions
by Alexandra Deriabina, Tatiana Prutskij, Hector Daniel Morales Ochoa, Eduardo Gonzalez Jimenez and Sergei Deriabin
Int. J. Mol. Sci. 2024, 25(5), 2558; https://doi.org/10.3390/ijms25052558 - 22 Feb 2024
Viewed by 620
Abstract
Myricetin is a flavonol with high antioxidant properties. In this research, the fluorescence emission of myricetin powder and its solutions in different solvents were measured and analyzed by comparing with the results of calculations. Comparison of the calculated and measured characteristic wavelengths allowed [...] Read more.
Myricetin is a flavonol with high antioxidant properties. In this research, the fluorescence emission of myricetin powder and its solutions in different solvents were measured and analyzed by comparing with the results of calculations. Comparison of the calculated and measured characteristic wavelengths allowed the identification of all the spectral features in the fluorescence spectra of myricetin powder and solutions with different concentrations. The computation was based on modeling the process of the excited state intermolecular proton transfer, which predicts the formation of tautomeric forms of the flavonol molecule. Characteristic emission wavelengths were obtained using TDDFT/M06-2X/6-31++G(d,p). To understand the influence of the hydroxyl groups in the B-ring of the flavonol molecule on the emission spectrum, we also compared the fluorescence spectra of myricetin with those of kaempferol and quercetin. Moreover, based on the analysis of the changes in the shape of the FL spectra with the concentration of the solution, a criterion for the complete dissolution of the flavonol powders was established, which is important for bioavailability of flavonoids. Full article
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10 pages, 5721 KiB  
Communication
Identification of One O-Methyltransferase Gene Involved in Methylated Flavonoid Biosynthesis Related to the UV-B Irradiation Response in Euphorbia lathyris
by Wanli Zhao, Long Huang, Shu Xu, Junzhi Wu, Fan Wang, Pirui Li, Linwei Li, Mei Tian, Xu Feng and Yu Chen
Int. J. Mol. Sci. 2024, 25(2), 782; https://doi.org/10.3390/ijms25020782 - 8 Jan 2024
Viewed by 789
Abstract
Flavonoids are ubiquitous polyphenolic compounds that play a vital role in plants’ defense response and medicinal efficacy. UV-B radiation is a vital environmental regulator governing flavonoid biosynthesis in plants. Many plants rapidly biosynthesize flavonoids as a response to UV-B stress conditions. Here, we [...] Read more.
Flavonoids are ubiquitous polyphenolic compounds that play a vital role in plants’ defense response and medicinal efficacy. UV-B radiation is a vital environmental regulator governing flavonoid biosynthesis in plants. Many plants rapidly biosynthesize flavonoids as a response to UV-B stress conditions. Here, we investigated the effects of flavonoid biosynthesis via UV-B irradiation in Euphorbia lathyris. We found that exposure of the E. lathyris callus to UV-B radiation sharply increased the level of one O-methyltransferase (ElOMT1) transcript and led to the biosynthesis of several methylated flavonoids. The methyltransferase ElOMT1 was expressed heterologously in E. coli, and we tested the catalytic activity of recombinant ElOMT1 with possible substrates, including caffeic acid, baicalin, and luteolin, in vitro. ElOMT1 could efficiently methylate when the hydroxyl groups were contained in the core nucleus of the flavonoid. This molecular characterization identifies a methyltransferase responsible for the chemical modification of the core flavonoid structure through methylation and helps reveal the mechanism of methylated flavonoid biosynthesis in Euphorbiaceae. This study identifies the O-methyltransferase that responds to UV-B irradiation and helps shed light on the mechanism of flavonoid biosynthesis in Euphorbia lathyris. Full article
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22 pages, 3038 KiB  
Article
A Comparative Study of the Inhibitory Effect of Some Flavonoids and a Conjugate of Taxifolin with Glyoxylic Acid on the Oxidative Burst of Neutrophils
by Victoria S. Shubina, Victoria I. Kozina and Yuri V. Shatalin
Int. J. Mol. Sci. 2023, 24(20), 15068; https://doi.org/10.3390/ijms242015068 - 11 Oct 2023
Cited by 1 | Viewed by 1038
Abstract
During the storage, processing, and digestion of flavonoid-rich foods and beverages, a condensation of flavonoids with toxic carbonyl compounds occurs. The effect of the resulting products on cells remains largely unknown. The aim of the present study was to evaluate the effects of [...] Read more.
During the storage, processing, and digestion of flavonoid-rich foods and beverages, a condensation of flavonoids with toxic carbonyl compounds occurs. The effect of the resulting products on cells remains largely unknown. The aim of the present study was to evaluate the effects of quercetin, taxifolin, catechin, eriodictyol, hesperetin, naringenin, and a condensation product of taxifolin with glyoxylic acid on the oxidative burst of neutrophils. It was found that the flavonoids and the condensation product inhibited the total production of ROS. Flavonoids decreased both the intra and extracellular ROS production. The condensation product had no effect on intracellular ROS production but effectively inhibited the extracellular production of ROS. Thus, the condensation of flavonoids with toxic carbonyl compounds may lead to the formation of compounds exhibiting potent inhibitory effects on the oxidative burst of neutrophils. The data also suggest that, during these reactions, the influence of a fraction of flavonoids and their polyphenolic derivatives on cellular functions may change. On the whole, the results of the study provide a better understanding of the effects of polyphenols on human health. In addition, these results reveal the structure–activity relationship of these polyphenols and may be useful in a search for new therapeutic agents against diseases associated with oxidative stress. Full article
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Review

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19 pages, 1722 KiB  
Review
Chemical Constituents of Stinging Nettle (Urtica dioica L.): A Comprehensive Review on Phenolic and Polyphenolic Compounds and Their Bioactivity
by Saša Đurović, Ivan Kojić, Danka Radić, Yulia A. Smyatskaya, Julia G. Bazarnova, Snežana Filip and Tomislav Tosti
Int. J. Mol. Sci. 2024, 25(6), 3430; https://doi.org/10.3390/ijms25063430 - 18 Mar 2024
Cited by 2 | Viewed by 1517
Abstract
Polyphenolic compounds are of great interest in today’s science. Naturally, they occur in plants and other sources in many different forms. Their wide range of biological activity has attracted the attention of the scientific community. One of the sources of phenolic compounds is [...] Read more.
Polyphenolic compounds are of great interest in today’s science. Naturally, they occur in plants and other sources in many different forms. Their wide range of biological activity has attracted the attention of the scientific community. One of the sources of phenolic compounds is stinging nettle (Urtica dioica L.), a common plant in almost all parts of the world. A long tradition of utilization and an interesting chemical profile make this plant a fascinating and extensive object of study. The chemical profile also allows this plant to be used as a food and a pigment source in the food, pharmaceutical, and cosmetic industries. Previously conducted studies found phenolic acids and polyphenolic compounds in root, stalk, and stinging nettle leaves. Different extraction techniques were usually used to isolate them from the leaves. Obtained extracts were used to investigate biological activity further or formulate different functional food products. This study aimed to collect all available knowledge about this plant, its chemical composition, and biological activity and to summarize this knowledge with particular attention to polyphenolic compounds and the activity and mechanisms of their actions. Full article
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