Transition Metals in the Host-Pathogen Interaction
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".
Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 32711
Special Issue Editors
Interests: transition metals and antioxidant enzymes in the host-pathogen interaction; metal transporters; pathogenic mechanisms favouring airways infection in cystic fibrosis
Special Issue Information
Dear Colleagues,
Metals play an essential role in all biological systems. In particular, metals such as zinc, iron, manganese, copper, cobalt, and nickel are essential cofactors in a large number of proteins that participate in important metabolic pathways and contribute to resistance to a variety of stress conditions. All microorganisms have evolved complex machinery to ensure an adequate supply of these elements, while avoiding their potentially toxic intracellular accumulations.
These problems are exacerbated in bacteria or fungi colonizing other organisms, as the immune response to infection involves several strategies to starve microbes of essential elements or to poison them with high amounts of metals. To circumvent such defense mechanisms pathogenic microorganisms have developed efficient strategies that allow them to cope with metal limitation/intoxication in the infected host.
This Special Issue is open to contributions on all possible aspects concerning the role of metals in host–pathogen interactions, including, for example, studies on metal transport systems, host responses that interfere with metal acquisition by infectious agents, or novel antimicrobial strategies that interfere with metal homeostasis in pathogenic species.
Prof. Dr. Andrea Battistoni
Dr. Serena Ammendola
Guest Editors
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Keywords
- Transition metals
- Metal cofactors
- Metal transport systems
- Metal sequestration
- Metal toxicity
- Nutritional immunity
- Metals and virulence
- Chelating agents
- Siderophores/metallophores
- Trojan horse drugs
- Host–pathogen interactions
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