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Life
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The Materno-Fetal Outcome of Pregnancies in Chronic Diseases
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The Materno-Fetal Outcome of Pregnancies in Chronic Diseases

A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Epidemiology".

Deadline for manuscript submissions: closed (25 December 2022) | Viewed by 6315

Special Issue Editors

Dr. Anca Emanuela Mușetescu

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Guest Editor
Department of Rheumatology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania
Interests: rheumatic diseases; musculoskeletal ultrasound; capillaroscopy
Dr. Anca Pantea Stoian

E-Mail Website
Guest Editor
Department of Diabetes, Nutrition and Metabolic Diseases, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: diabetes; nutrition; metabolic diseases
Special Issues, Collections and Topics in MDPI journals
Dr. Anca Bobircă

E-Mail Website
Guest Editor
Department of Rheumatology and Internal Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: autoimmune and inflammatory rheumatic diseases; pregnancy in rheumatic diseases; inheritance of rheumatic diseases

Special Issue Information

Dear Colleagues,

At their reproductive age, patients with chronic conditions have a higher risk of pregnancy complications, both maternal and fetal. Chronic illnesses and risk factors have been associated over time with maternal complications, gestational diabetes and pre-eclampsia (the latter being the most prevalent). Nevertheless, the extent of chronic diseases is vast, ranging from cardiovascular, endocrine, nutritional, neurologic, rheumatic, hematologic, nephrology, to ophthalmologic and even dermatologic conditions. The study of maternal and fetal outcomes of pregnancy in chronic diseases is of great importance in order to help our patients plan a pregnancy, better define medication compatibility, to have a favorable maternal and fetal outcome and also better understand the long-term effects on children. Familial aggregation represents the Achilles’ heel among patients with chronic diseases who plan a pregnancy, due to the fear of transmission. The aim of this Special Issue is to better understand the complex situations that may arise during pregnancy in patients with chronic illnesses, to establish the most prevalent adverse pregnancy events and the transmissibility of certain diseases. We are delighted to invite you to submit your papers covering your clinical experience, as well as the current knowledge and recommendations in this domain.

Dr. Anca Emanuela Mușetescu
Dr. Anca Pantea Stoian
Dr. Anca Bobircă
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Life is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pregnancy in chronic diseases
  • pregnancy outcome
  • children follow- up
  • familial aggregation

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Published Papers (2 papers)

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Research

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10 pages, 955 KiB  
Article
Does a Single Exposure to General Anesthesia Have a Cumulative Effect on the Developing Brain after Mild Perinatal Asphyxia?
by Sebastian Isac, Bogdan Pavel, Maria Dobre, Elena Milanesi, Irina-Mihaela Matache, Raul-Mihai Paun, Artsiom Klimko, Mara Ioana Iesanu, Gabriela Droc and Ana-Maria Zagrean
Life 2022, 12(10), 1568; https://doi.org/10.3390/life12101568 - 9 Oct 2022
Cited by 1 | Viewed by 1926
Abstract
Background: General anesthesia (GA) in pediatric patients represents a clinical routine. Factors such as increased birth age and maternal chronic conditions cause more infants to experience hypoxic-ischemic encephalopathy, an additional risk for anesthesia. Aim: This study evaluates the effect of one sevoflurane-induced GA [...] Read more.
Background: General anesthesia (GA) in pediatric patients represents a clinical routine. Factors such as increased birth age and maternal chronic conditions cause more infants to experience hypoxic-ischemic encephalopathy, an additional risk for anesthesia. Aim: This study evaluates the effect of one sevoflurane-induced GA episode on the immature brain previously exposed to perinatal asphyxia (PA). Methods: Postnatal day 6 (PND6) Wistar rats were exposed to a 90-min episode of normoxia/PA and at PND15 to a 120-min episode of normoxia/GA. Four groups were analyzed: Control (C), PA, GA, and PA-GA. Post-exposures, fifteen pups/group were sacrificed and the hippocampi were isolated to assess S-100B and IL-1B protein levels, using ELISA. At maturity, the behavior was assessed by: forced swimming test (FST), and novel object recognition test. Results: Hippocampal S-100B level was increased in PA, GA, and PA-GA groups, while IL-1B was increased in PA, but decreased in PA-GA. The immobility time was increased in PA and PA-GA, in FST. Conclusions: Both PA and GA contribute to glial activation, however with no cumulative effect. Moreover, PA reduces the rats’ mobility, irrespective of GA exposure, while memory evaluated by the novel object recognition test was not influenced. Full article
(This article belongs to the Special Issue The Materno-Fetal Outcome of Pregnancies in Chronic Diseases)
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Review

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24 pages, 472 KiB  
Review
Pregnancy in Patients with Inflammatory Bowel Diseases—A Literature Review
by Raluca Roxana Grigorescu, Ioana Alexandra Husar-Sburlan, Georgiana Rosulescu, Anca Bobirca, Razvan Cerban, Florin Bobirca and Madalina Marieta Florescu
Life 2023, 13(2), 475; https://doi.org/10.3390/life13020475 - 9 Feb 2023
Cited by 2 | Viewed by 3533
Abstract
In recent years, we have faced an increasing incidence of inflammatory bowel disease (IBD), especially among young people, affecting them during their reproductive years. The paucity of data and reduced knowledge regarding the evolution of the disease during pregnancy and the adverse effects [...] Read more.
In recent years, we have faced an increasing incidence of inflammatory bowel disease (IBD), especially among young people, affecting them during their reproductive years. The paucity of data and reduced knowledge regarding the evolution of the disease during pregnancy and the adverse effects of the therapy on the mother and infant increase voluntary childlessness in this group of patients. Depending on the type of IBD, severity and surgical or medical management, this can negatively affect the pregnancy. C-sections and the risk of low-birth-weight babies are higher in women with IBD, independent of active/inactive disease, while preterm birth, stillbirth and miscarriage are associated with disease activity. In the last period, medicinal therapy has evolved, and new molecules have been developed for better control of the lesions, but the effect on pregnancy and breastfeeding is still controversial. We conducted this review by studying the literature and recent research in order to have a better image of the practical management of IBD during pregnancy. Full article
(This article belongs to the Special Issue The Materno-Fetal Outcome of Pregnancies in Chronic Diseases)
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