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Medicina
Special Issues
Clinical Management of Diabetes and Complications
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Clinical Management of Diabetes and Complications

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Endocrinology".

Deadline for manuscript submissions: 25 March 2026 | Viewed by 757

Special Issue Editors

Dr. Anca Pantea Stoian

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Guest Editor
Department of Diabetes, Nutrition and Metabolic Diseases, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania
Interests: obesity; diabetes mellitus; MAFLD; renal failure; metabolic syndrome; prediabetes; atherosclerosis; metabolic inflammation; insulin resistance
Special Issues, Collections and Topics in MDPI journals
Dr. Delia V. Reurean-Pintilei

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Guest Editor Assistant
Department of Medical-Surgical and Complementary Sciences, Faculty of Medicine and Biological Sciences, “Stefan cel Mare” University, 720229 Suceava, Romania
Interests: type 2 diabetes mellitus; obesity; insulin resistance; atherosclerosis; cardiovascular risk; metabolic syndrome; diabetes technology; cardiorenal–metabolic interactions; diabetes complications; digital health; diabetes education

Special Issue Information

Dear Colleagues,

The clinical management of diabetes and its complications represents a central challenge in contemporary medicine, requiring continuous adaptation to emerging therapies, comorbidities, and patient needs. This Special Issue, “Clinical Management of Diabetes and Complications”, aims to provide a comprehensive overview of current clinical strategies and emerging therapeutic options in the management of diabetes and its associated complications.

This Special Issue will address advances in pharmacological treatment—including novel antidiabetic agents with proven cardiorenal–metabolic benefits—as well as lifestyle and digital interventions for glycaemic and complication control. Particular focus will be given to the early recognition and individualized management of diabetic complications such as cardiovascular disease, nephropathy, neuropathy, retinopathy, and diabetic foot syndrome.

We will also explore comorbid conditions closely linked to the pathophysiology of diabetes, such as obesity and metabolic dysfunction-associated fatty liver disease (MAFLD), which play growing roles in cardiovascular as well as metabolic risk assessment and therapeutic decision making. In addition, contributions on diabetes remission—through nutritional interventions, bariatric surgery, or pharmacotherapy—are encouraged, reflecting a paradigm shift in the long-term management of type 2 diabetes.

We welcome papers exploring innovative care models, structured education programs, and integrated multidisciplinary approaches, with the aim to improve the outcomes and quality of life of people living with diabetes. Additionally, the use of artificial intelligence, continuous glucose monitoring systems, insulin delivery devices, remote monitoring, and precision medicine in diabetes care will be considered as priorities.

Original research articles, clinical trials, systematic reviews, and expert perspectives contributing to the optimization of care in diabetes and its complications are invited. This Special Issue welcomes submissions from both clinical and translational researchers for evidence-based, patient-centred approaches.

Dr. Anca Pantea Stoian
Guest Editor

Dr. Delia V. Reurean-Pintilei
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetic complications’ multidisciplinary management
  • MAFLD
  • diabetes remission
  • cardiovascular risk
  • precision medicine
  • antidiabetic therapy
  • diabetes mellitus
  • digital health
  • chronic disease management
  • obesity

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

16 pages, 2218 KiB  
Article
The Effectiveness of Semaglutide on a Composite Endpoint of Glycemic Control and Weight Reduction and Its Effect on Lipid Profile Among Obese Type 2 Diabetes Patients
by Sumaiah J. Alarfaj
Medicina 2025, 61(8), 1393; https://doi.org/10.3390/medicina61081393 - 31 Jul 2025
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Abstract
Background and Objectives: Obesity and type 2 diabetes (T2D) are closely linked and associated with a higher risk of complications. This study aims to evaluate the effectiveness of once-weekly semaglutide in achieving a composite endpoint of A1C and weight reduction. Materials and Methods: [...] Read more.
Background and Objectives: Obesity and type 2 diabetes (T2D) are closely linked and associated with a higher risk of complications. This study aims to evaluate the effectiveness of once-weekly semaglutide in achieving a composite endpoint of A1C and weight reduction. Materials and Methods: This retrospective cohort study assessed the effectiveness of semaglutide in obese patients with T2D at a tertiary care hospital in Saudi Arabia. This study included patients who received semaglutide treatment for 12 months, and the endpoint was reducing A1C by ≥ 1% and body weight by ≥ 5% after 12 months of starting semaglutide. Secondary endpoints include predictors of achieving the composite endpoint and the effect on the lipid profile. Results: The present study enrolled 459 participants, with dyslipidemia and hypertension being the most common comorbidities. After 12 months of treatment with semaglutide, 42% of the patients achieved the composite endpoint. Semaglutide significantly reduced weight, BMI, A1C, FBG, total cholesterol, LDL, and triglycerides. The subgroup analysis showed that patients who achieved the composite endpoint were younger and had significantly lower use of insulin. Females in the study had significantly higher BMI, A1C, and HDL levels and lower levels of triglycerides compared to males. Multivariate analysis revealed that baseline BMI (aOR = 0.953; 95% CI: 0.915 to 0.992; p = 0.02), baseline A1C (aOR = 1.213; 95% CI: 1.062 to 1.385; p = 0.004), and receiving insulin (aOR = 0.02; 95% CI: 0.001 to 0.343; p = 0.007) were significant predictors of composite endpoint achievement. Conclusions: Semaglutide is a valuable option for the treatment of obese patients with T2D. This study found that semaglutide is effective in reducing weight and A1C and improving the lipid profile. The predictors of achievement of the composite endpoint were lower baseline BMI, higher baseline A1C, and insulin non-use. Full article
(This article belongs to the Special Issue Clinical Management of Diabetes and Complications)
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18 pages, 1736 KiB  
Article
Does the Interaction Between Alcohol Use and Depression Exacerbate Hyperglycemia Risk? A Cross-Sectional Study Beyond Additive Effects
by Simona-Dana Mitincu-Caramfil, Anca Pantea Stoian, Lavinia-Alexandra Moroianu, Catalin Plesea-Condratovici, Andrei Vlad Bradeanu and Eduard Drima
Medicina 2025, 61(8), 1380; https://doi.org/10.3390/medicina61081380 - 30 Jul 2025
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Abstract
Background and Objectives: This study investigated whether the interaction between heavy alcohol use and depression amplifies the risk of hyperglycemia in psychiatric patients. Materials and Methods: We conducted a cross-sectional study on 172 patients (aged 18–65) hospitalized at the “Elisabeta Doamna” [...] Read more.
Background and Objectives: This study investigated whether the interaction between heavy alcohol use and depression amplifies the risk of hyperglycemia in psychiatric patients. Materials and Methods: We conducted a cross-sectional study on 172 patients (aged 18–65) hospitalized at the “Elisabeta Doamna” Clinical Psychiatric Hospital, Romania. The data included fasting blood glucose, gamma-glutamyl transferase (GGT), Beck Depression Inventory (BDI), and Alcohol Use Disorders Identification Test (AUDIT) scores. Results: Moderate positive correlations were observed between depression scores and blood glucose (r = 0.44) and between alcohol consumption and blood glucose (r = 0.43). The interaction term (BDI × AUDIT) was statistically significant in multiple regression (β = 0.012, p = 0.001), and the model explained 39.1% of glucose variability. Logistic regression analysis revealed that neither high alcohol consumption (OR = 1.38, p = 0.441) nor severe depression alone (OR = 1.30, p = 0.582) were significantly associated with hyperglycemia. However, their interaction demonstrated a strong and statistically significant effect (OR = 19.3, 95% CI: 3.22–115.81, p = 0.001). The prevalence of hyperglycemia reached 95.8% in patients with both risk factors. Conclusions: The combined presence of high alcohol consumption and severe depression significantly increases the risk of hyperglycemia. These findings highlight the importance of integrated screening and interventions in psychiatric settings. Full article
(This article belongs to the Special Issue Clinical Management of Diabetes and Complications)
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