Etiology and Pathogenesis of Pulpitis and Apical Periodontitis 2023
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 February 2025) | Viewed by 4130
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Dear Colleagues,
The apical periodontitis is an infection-driven, chronic inflammatory disease, which usually leads to the destruction of periodontal tissues, the alveolar bone, and impaired dentition. Uncontrolled infection of periapical tissues through a bacterial infection in the root canal might result in extensive bone resorption around the root that ultimately leads to tooth loss if left untreated. Therefore, pulpitis and apical periodontitis impact a patient’s quality of life and cause significant burdens.
The apical periodontitis occurs due to the long-term infection and pathogenic irritants in the root canal. These bacteria inhabit anatomical locations that are inaccessible to macrophages and other immune cells, such as dentin tubules, thus creating conditions for bacteria to directly damage tissue and secrete enzymes, exotoxins, and metabolic end products to regulate the immune response. The presence of microbial factors stimulates an immune response, producing a series of pathological manifestations, mainly inflammation affecting the bone tissue. Thus, its pathogenesis, prevention and treatment are a challenge for the clinicians. During treatment, infection control should be resolved first, and periapical bone remodeling should be carried out on this basis.
The aim of the present Special Issue is to gather manuscripts (original articles and reviews) that address questions related to the pulpitis and apical periodontitis physiopathology, ranging from the pathogenesis to the therapeutic approaches in animal models and/or clinical trials.
Dr. Rafael Scaf De Molon
Guest Editor
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