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Int. J. Mol. Sci. 2015, 16(8), 16833-16847;

The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer

Department of Biopharmaceutical Sciences, University of Illinois at Chicago, 833 S Wood Street, 335 College of Pharmacy Building, Chicago, IL 60612, USA
Author to whom correspondence should be addressed.
Academic Editors: Michael R. Ladomery and Michael Ibba
Received: 29 April 2015 / Revised: 29 June 2015 / Accepted: 8 July 2015 / Published: 24 July 2015
(This article belongs to the Special Issue RNA Interference)
Full-Text   |   PDF [929 KB, uploaded 24 July 2015]   |  


The role of microRNAs (miRNAs or miRs) in the pathology of epithelial ovarian cancer (EOC) has been extensively studied. Many miRNAs differentially expressed in EOC as compared to normal controls have been identified, prompting further inquiry into their role in the disease. miRNAs belonging to the miR-200 family have repeatedly surfaced over multiple profiling studies. In this review, we attempt to consolidate the data from different studies and highlight mechanisms by which these miRNAs influence progression of metastasis and chemo-resistance in EOC. View Full-Text
Keywords: ovarian carcinoma; miR-200 family; metastasis; chemoresistance; expression ovarian carcinoma; miR-200 family; metastasis; chemoresistance; expression

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Muralidhar, G.G.; Barbolina, M.V. The miR-200 Family: Versatile Players in Epithelial Ovarian Cancer. Int. J. Mol. Sci. 2015, 16, 16833-16847.

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