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Special Issue "Neuroinflammation and Psychiatric Disorders: From Mechanisms to Therapy Potential"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2018).
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada
Interests: neuroimaging; schziophrenia; psychosis; psychosis risk; neuroinflammation; positron emission tomography; endocannabinoid system; dopaminergic system; stress
Neuroinflammation and abnormal immune function are suggested to contribute to the development and progression of several psychiatric disorders including (but not limited to) neurodegenerative diseases, autism spectrum disorder and schizophrenia. However, the exact mechanisms underlying the link between these pathophysiological factors and psychiatric disorders are still not clear. Preclinical studies have shown immune abnormalities in animal models of psychiatric disorders. In addition, some immune modulators can induce symptoms resembling psychiatric disorders in animals. Another line of evidence is based on genome-wide association studies showing association between immune-related genes and psychiatric disorders. Supporting this, epidemiological studies have provided evidence for the link between maternal infections during pregnancy and risk of some psychiatric disorders (e.g., autism and schizophrenia) in offspring. One of the most important implications of this research pertains to identification of new targets for novel treatments; as there is a growing body of literature on the role of immune-modulatory medications in prevention and/or treatment of psychiatric disorders. While the role of non-steroidal anti-inflammatory drugs or supplements, such as omega-3 fatty acids is controversial (at best) for neurodegenerative or neurodevelopmental diseases, future studies should aim for more specific therapies. In this Special Issue, we solicit manuscripts that address any aspects of the connection between neuroinflammation and psychiatric disorders; more importantly articles that illustrate how our current understanding of these pathological factors can help in developing novel treatments.
Prof. Dr. Romina Mizrahi
Dr. Sina Hafizi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- blood-brain barrier
- immune system