Special Issue "Prions and Prion Diseases 2.0"
Deadline for manuscript submissions: 30 September 2021.
Interests: prions; neurodegenerative disorders; amyloid; neuronal cell death; protein aggregation
Special Issues and Collections in MDPI journals
Prion diseases, which include Creutzfeldt–Jakob disease in humans and scrapie and bovine spongiform encephalopathy in animals, are caused by accumulation of proteinaceous infectious particles, or the so-called prions, in the brain. Conformational conversion of the normal cellular isoform of prion protein, designated PrPC, into the relatively protease-resistant, amyloidogenic isoform, PrPSc, is the underlying mechanism of prion propagation and subsequent degenerative neuronal cell death. Although extensive studies have uncovered many aspects of prion diseases, the diseases still remain incurable. Therefore, further studies for elucidation of the molecular pathogenic mechanisms of the diseases and development of therapeutic interventions against prion diseases are still crucial.
This Special Issue calls for original articles, reviews, and perspectives in relevant research fields, including those for the normal function of PrPC, the neurotoxic mechanism of PrPSc, structural studies of PrPSc, the conversion mechanism of PrPC into PrPSc, elucidation of the molecular mechanism of hereditary prion diseases in humans and animal models, and interventional approaches against prion diseases. Studies on nonmammalian prions are also welcome.
Prof. Suehiro Sakaguchi
Manuscript Submission Information
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- Prion protein
- Protein conformation
- Creutzfeldt–Jakob disease
- Bovine spongiform encephalopathy