Endogenous Gaseous Signaling Molecules: Their Mechanism(s) of Action and Pharmacological Effects
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 40618
Special Issue Editors
Interests: gaseous mediators; hydrogen sulfide; carbon monoxide; molecular gastroenterology; gastrointestinal pharmacology; Barrett’s esophagus; digestive system pathologies
Special Issues, Collections and Topics in MDPI journals
Interests: drug design; organic synthesis; drug delivery; computational chemistry; drug screening; instrument analysis; cell culture; biochemistry; enzyme inhibition; fluorescent sensing; click chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Endogenously produced gaseous signaling molecules such as hydrogen sulfide (H2S), nitric oxide (NO) and carbon monoxide (CO) have been shown to exert anti-inflammatory, vasoactive and anti-oxidative effects, among many other properties. Their pleiotropic effects raise an intriguing question about their mechanism(s) of action (MOA(s)). CO is known to affect the synthesis of cyclic guanosine monophosphate (cGMP) via the activation of soluble guanylyl cyclase (sGC), inhibit CBS and cytochrome c oxidase, and affect ion channels. Similarly, NO diffuses from the endothelium to smooth muscle, located in the vascular wall, where it also activates sGC, leading to a rise in cGMP levels. H2S, on the other hand, is an anti-oxidant and seems to affect ATP-dependent potassium ion channels. These are just examples of their MOAs. Moreover, H2S-releasing hybrids of non-steroidal anti-inflammatory drugs have been shown to reduce the gastrointestinal side effects and gastrotoxicity characteristic of the parent drugs. Therefore, a variety of CO, H2S and NO donors have been developed and are now available for preclinical pharmacological assessment. Some of these compounds are currently at the stage of clinical trials. However, there is much more to be done in developing pharmaceutically acceptable donors of these gaseous signaling molecules and in understanding the MOAs for their pleiotropic effects.
This Special Issue of the International Journal of Molecular Sciences aims to gather articles focused on recent developments in the study of H2S, NO or CO, either produced endogenously or delivered from pharmaceutical donors, in health and disease. Review articles or manuscripts on original research regarding H2S, CO or NO donors, the cross-talk among these signaling molecules, or their novel mechanisms are within the scope of this Special Issue.
Dr. Marcin Magierowski
Prof. Dr. Binghe Wang
Guest Editors
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Keywords
- hydrogen sulfide
- carbon monoxide
- nitric oxide
- molecular pharmacology
- donors
- prodrugs
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