Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms

Zhang, Max Y.; Dugbartey, George J.; Juriasingani, Smriti; Sener, Alp

doi:10.3390/ijms22126452

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Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms

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Matthew Mailing Center for Translational Transplant Studies, London Health Sciences Center, Western University, London, ON N6A 5A5, Canada

London Health Sciences Center, Multi-Organ Transplant Program, Western University, London, ON N6A 5A5, Canada

London Health Sciences Center, Department of Surgery, Division of Urology, Western University, London, ON N6A 5A5, Canada

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Department of Microbiology & Immunology, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada

Author to whom correspondence should be addressed.

Academic Editor: Marcin Magierowski

Int. J. Mol. Sci. 2021, 22(12), 6452; https://doi.org/10.3390/ijms22126452

Received: 28 May 2021 / Revised: 10 June 2021 / Accepted: 11 June 2021 / Published: 16 June 2021

(This article belongs to the Special Issue Endogenous Gaseous Signaling Molecules: Their Mechanism(s) of Action and Pharmacological Effects)

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Abstract

Thiosulfate in the form of sodium thiosulfate (STS) is a major oxidation product of hydrogen sulfide (H₂S), an endogenous signaling molecule and the third member of the gasotransmitter family. STS is currently used in the clinical treatment of acute cyanide poisoning, cisplatin toxicities in cancer therapy, and calciphylaxis in dialysis patients. Burgeoning evidence show that STS has antioxidant and anti-inflammatory properties, making it a potential therapeutic candidate molecule that can target multiple molecular pathways in various diseases and drug-induced toxicities. This review discusses the biochemical and molecular pathways in the generation of STS from H₂S, its clinical usefulness, and potential clinical applications, as well as the molecular mechanisms underlying these clinical applications and a future perspective in kidney transplantation. View Full-Text

Keywords: sodium thiosulfate (STS); thiosulfate; hydrogen sulfide (H₂S); ischemia–reperfusion injury (IRI); sulfide oxidation pathway

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Zhang, M.Y.; Dugbartey, G.J.; Juriasingani, S.; Sener, A. Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms. Int. J. Mol. Sci. 2021, 22, 6452. https://doi.org/10.3390/ijms22126452

AMA Style

Zhang MY, Dugbartey GJ, Juriasingani S, Sener A. Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms. International Journal of Molecular Sciences. 2021; 22(12):6452. https://doi.org/10.3390/ijms22126452

Chicago/Turabian Style

Zhang, Max Y., George J. Dugbartey, Smriti Juriasingani, and Alp Sener. 2021. "Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms" International Journal of Molecular Sciences 22, no. 12: 6452. https://doi.org/10.3390/ijms22126452

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Hydrogen Sulfide Metabolite, Sodium Thiosulfate: Clinical Applications and Underlying Molecular Mechanisms

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