ijms-logo

Journal Browser

Journal Browser

Plant Bioactive Compounds: Antioxidant, Anti-inflammatory and Anticancer Effects

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 3446

Special Issue Editor


E-Mail Website
Guest Editor
Department of Technical and Natural Sciences, Faculty of Food Engineering, Tourism and Environmental Protection, Aurel Vlaicu University of Arad, 310330 Arad, Romania
Interests: phytochemicals; health, analytical, and natural product chemistry; peptides and proteins; drug discovery; drug delivery systems; synthesis/green synthesis of biologically active molecules and nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plant-derived bioactive compounds serve as crucial components for pharmaceuticals, nutritional products, and traditional medicine. Understanding the intricate molecular processes associated with the health-promoting properties of these diverse bioactive compounds is essential for developing targeted products.

This particular Special Issue is dedicated to recent research that explores the acquisition, identification, and utilization of bioactive compounds. The primary focus is on elucidating the molecular mechanisms and cellular pathways implicated in conditions such as metabolic diseases, skin disorders, cancer, and more. Contributions that furnish insights into the molecular targets of these compounds, their impact at the cellular, organ, and organism levels, and their modulation of various cellular pathways and functions are highly encouraged.

The objective of this Special Issue is to unravel the molecular foundations underlying the incorporation of phytochemicals in pharmaceuticals and nutraceuticals, as well as in the development of new drugs. The scope spans from laboratory research to preclinical applications, emphasizing a comprehensive understanding of the molecular basis for these compounds in promoting human health.

IJMS focuses on molecular studies in biology and chemistry, with a strong emphasis on molecular biology and molecular medicine.

Substances without clear ingredients, such as complex prescriptions, crude extracts, and herbal mixtures, are not considered.

Papers that only contain clinical trials/data are not acceptable for publication in IJMS.

Prof. Dr. Dana Maria Copolovici
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer
  • antioxidant
  • anti-inflammatory
  • bioactive compounds
  • chemical biology
  • molecular biology
  • metabolic diseases
  • nutrition.

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

20 pages, 2607 KiB  
Article
Triterpenoid Saponins and Flavonoid Glycosides from the Flower of Camellia flavida and Their Cytotoxic and α-Glycosidase Inhibitory Activities
by Siyuan Ma, Yuxin Wu, Hanfeng Min, Li Ge and Kedi Yang
Int. J. Mol. Sci. 2024, 25(20), 10977; https://doi.org/10.3390/ijms252010977 - 12 Oct 2024
Viewed by 1202
Abstract
Camellia flavida var. flavida, commonly known as “Jinhua Tea”, has its flowers and leaves traditionally utilized as tea and functional food sources. However, there is limited knowledge about its bioactive components and their biological activities. This study isolated ten previously unidentified glycoside compounds [...] Read more.
Camellia flavida var. flavida, commonly known as “Jinhua Tea”, has its flowers and leaves traditionally utilized as tea and functional food sources. However, there is limited knowledge about its bioactive components and their biological activities. This study isolated ten previously unidentified glycoside compounds from the flowers of Camellia flavida, including three oleanane-type triterpenoid saponins (compounds 13) and seven flavonoid glycosides (compounds 410), collectively named flavidosides A–J. This study assessed the cytotoxicity of these compounds against a panel of human cancer cell lines and their α-glucosidase inhibitory activities. Notably, flavidoside C showed significant cytotoxicity against BEL-7402 and MCF-7 cell lines, with IC50 values of 4.94 ± 0.41 and 1.65 ± 0.39 μM, respectively. Flavidoside H exhibited potent α-glucosidase inhibitory activity, with an IC50 value of 1.17 ± 0.30 mM. These findings underscore the potential of Camellia flavida in the development of functional foods. Full article
Show Figures

Figure 1

11 pages, 2379 KiB  
Article
Effects of Hydroxysafflor Yellow A (HSYA) on UVA-Induced Damage in HaCaT Keratinocytes
by Szu-Chieh Yu, Wan-Chun Chiu, Pei Yu Loe and Yi-Wen Chien
Int. J. Mol. Sci. 2024, 25(14), 7573; https://doi.org/10.3390/ijms25147573 - 10 Jul 2024
Cited by 2 | Viewed by 1388
Abstract
To assess the effects of hydroxysafflor yellow A (HSYA) on ultraviolet A (UVA)-induced damage in HaCaT keratinocytes. HaCaT keratinocytes were UVA-irradiated, and the effects of HSYA on cell viability, reactive oxygen species (ROS) generation, lipid peroxidation, and messenger (m)RNA expression were measured. mRNA [...] Read more.
To assess the effects of hydroxysafflor yellow A (HSYA) on ultraviolet A (UVA)-induced damage in HaCaT keratinocytes. HaCaT keratinocytes were UVA-irradiated, and the effects of HSYA on cell viability, reactive oxygen species (ROS) generation, lipid peroxidation, and messenger (m)RNA expression were measured. mRNA expressions of matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, and cyclooxygenase (COX)-2 were determined by a real-time polymerase chain reaction (RT-PCR). UVA exposure led to a decrease in cell viability and an increase in ROS generation in HaCaT keratinocytes. HSYA effectively increased the viability of HaCaT keratinocytes after UVA exposure and protected them from UVA-induced oxidative stress. Moreover, HSYA inhibited expressions of MMP-1, MMP-2, MMP-9, and COX-2 by HaCaT keratinocytes with UVA-induced photodamage. Our results suggest that HSYA can act as a free radical scavenger when keratinocytes are photodamaged. HSYA has the potential to be a skin-protective ingredient against UVA-induced photodamage. Full article
Show Figures

Figure 1

Back to TopTop