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Plant Bioactive Compounds: Antioxidant, Anti-inflammatory and Anticancer Effects

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 November 2024 | Viewed by 655

Special Issue Editor


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Guest Editor
Department of Technical and Natural Sciences, Faculty of Food Engineering, Tourism and Environmental Protection, Aurel Vlaicu University of Arad, 310330 Arad, Romania
Interests: phytochemicals; health, analytical, and natural product chemistry; peptides and proteins; drug discovery; drug delivery systems; synthesis/green synthesis of biologically active molecules and nanoparticles
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Special Issue Information

Dear Colleagues,

Plant-derived bioactive compounds serve as crucial components for pharmaceuticals, nutritional products, and traditional medicine. Understanding the intricate molecular processes associated with the health-promoting properties of these diverse bioactive compounds is essential for developing targeted products.

This particular Special Issue is dedicated to recent research that explores the acquisition, identification, and utilization of bioactive compounds. The primary focus is on elucidating the molecular mechanisms and cellular pathways implicated in conditions such as metabolic diseases, skin disorders, cancer, and more. Contributions that furnish insights into the molecular targets of these compounds, their impact at the cellular, organ, and organism levels, and their modulation of various cellular pathways and functions are highly encouraged.

The objective of this Special Issue is to unravel the molecular foundations underlying the incorporation of phytochemicals in pharmaceuticals and nutraceuticals, as well as in the development of new drugs. The scope spans from laboratory research to preclinical applications, emphasizing a comprehensive understanding of the molecular basis for these compounds in promoting human health.

IJMS focuses on molecular studies in biology and chemistry, with a strong emphasis on molecular biology and molecular medicine.

Substances without clear ingredients, such as complex prescriptions, crude extracts, and herbal mixtures, are not considered.

Papers that only contain clinical trials/data are not acceptable for publication in IJMS.

Prof. Dr. Dana Maria Copolovici
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • anticancer
  • antioxidant
  • anti-inflammatory
  • bioactive compounds
  • chemical biology
  • molecular biology
  • metabolic diseases
  • nutrition.

Published Papers (1 paper)

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Research

11 pages, 2379 KiB  
Article
Effects of Hydroxysafflor Yellow A (HSYA) on UVA-Induced Damage in HaCaT Keratinocytes
by Szu-Chieh Yu, Wan-Chun Chiu, Pei Yu Loe and Yi-Wen Chien
Int. J. Mol. Sci. 2024, 25(14), 7573; https://doi.org/10.3390/ijms25147573 - 10 Jul 2024
Viewed by 270
Abstract
To assess the effects of hydroxysafflor yellow A (HSYA) on ultraviolet A (UVA)-induced damage in HaCaT keratinocytes. HaCaT keratinocytes were UVA-irradiated, and the effects of HSYA on cell viability, reactive oxygen species (ROS) generation, lipid peroxidation, and messenger (m)RNA expression were measured. mRNA [...] Read more.
To assess the effects of hydroxysafflor yellow A (HSYA) on ultraviolet A (UVA)-induced damage in HaCaT keratinocytes. HaCaT keratinocytes were UVA-irradiated, and the effects of HSYA on cell viability, reactive oxygen species (ROS) generation, lipid peroxidation, and messenger (m)RNA expression were measured. mRNA expressions of matrix metalloproteinase (MMP)-1, MMP-2, MMP-9, and cyclooxygenase (COX)-2 were determined by a real-time polymerase chain reaction (RT-PCR). UVA exposure led to a decrease in cell viability and an increase in ROS generation in HaCaT keratinocytes. HSYA effectively increased the viability of HaCaT keratinocytes after UVA exposure and protected them from UVA-induced oxidative stress. Moreover, HSYA inhibited expressions of MMP-1, MMP-2, MMP-9, and COX-2 by HaCaT keratinocytes with UVA-induced photodamage. Our results suggest that HSYA can act as a free radical scavenger when keratinocytes are photodamaged. HSYA has the potential to be a skin-protective ingredient against UVA-induced photodamage. Full article
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