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Special Issue "Molecular Mechanisms of Obesity-Associated Vascular Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 September 2020.

Special Issue Editor

Dr. Kyoichiro Tsuchiya
Website
Guest Editor
Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
Interests: diabetes; obesity; atherosclerosis

Special Issue Information

Dear Colleagues,

Research on the high prevalence of obesity throughout the world has increasingly focused on the association between body weight, cardiovascular risk factors, and clinical cardiovascular disease (CVD). In particular, obesity is associated with numerous CVD co-morbidities such as atherosclerosis, aortic aneurysm, and heart failure, as well as with an increased risk of morbidity and mortality and reduced life expectancy. This Special Issue of IJMS is focused on the molecular mechanisms of obesity-associated vascular diseases. We welcome unique and creative basic researches on the relationship among obesity, inflammation, and CVD and on adipose tissue-derived cytokines known to affect vascular homeostasis. We look forward to your contributions.

Dr. Kyoichiro Tsuchiya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • obesity
  • inflammation
  • cardiovascular disease
  • adipose tissue-derived cytokines

Published Papers (1 paper)

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Review

Open AccessReview
Vascular Homeostasis and Inflammation in Health and Disease—Lessons from Single Cell Technologies
Int. J. Mol. Sci. 2020, 21(13), 4688; https://doi.org/10.3390/ijms21134688 - 30 Jun 2020
Abstract
The vascular system is critical infrastructure that transports oxygen and nutrients around the body, and dynamically adapts its function to an array of environmental changes. To fulfil the demands of diverse organs, each with unique functions and requirements, the vascular system displays vast [...] Read more.
The vascular system is critical infrastructure that transports oxygen and nutrients around the body, and dynamically adapts its function to an array of environmental changes. To fulfil the demands of diverse organs, each with unique functions and requirements, the vascular system displays vast regional heterogeneity as well as specialized cell types. Our understanding of the heterogeneity of vascular cells and the molecular mechanisms that regulate their function is beginning to benefit greatly from the rapid development of single cell technologies. Recent studies have started to analyze and map vascular beds in a range of organs in healthy and diseased states at single cell resolution. The current review focuses on recent biological insights on the vascular system garnered from single cell analyses. We cover the themes of vascular heterogeneity, phenotypic plasticity of vascular cells in pathologies such as atherosclerosis and cardiovascular disease, as well as the contribution of defective microvasculature to the development of neurodegenerative disorders such as Alzheimer’s disease. Further adaptation of single cell technologies to study the vascular system will be pivotal in uncovering the mechanisms that drive the array of diseases underpinned by vascular dysfunction. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Obesity-Associated Vascular Disease)
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