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Molecular Insight into Dentistry and Craniofacial Surgery: Celebrating the 110th Anniversary of Dentistry in Italy

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 1537

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Guest Editor
Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania, Luigi Vanvitelli, 80138 Naples, Italy
Interests: temporomandibular disorders; TED; temporomandibular joint; orofacial pain; dentistry; telemedicine; tele dentistry; implant; prosthesis; oral surgery
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Special Issue Information

Dear Colleagues,

In the last 100 years, dentistry has broadened its scope due to the increase in research, and numerous innovations in technology and in the digital and molecular sciences. The applications of new materials and techniques can lead to significant advances in the main dental branches, such as restorative dentistry, prosthodontics, oral surgery, implantology, pediatric dentistry, orthodontics, and temporomandibular disorder patients.

In this Special Issue, we would like to focus on the most recent and significant innovations in the dental field, particularly research at a molecular research level. Authors that have conducted studies on these themes are welcome to submit original research articles, reviews and short communications.

Dr. Giuseppe Minervini
Guest Editor

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Keywords

  • dentistry
  • craniofacial district
  • technological
  • oral health
  • molecular research
  • materials
  • restorative dentistry
  • prosthodontics
  • oral surgery
  • implantology
  • pediatric dentistry
  • orthodontics
  • temporomandibular disorder

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Published Papers (1 paper)

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Research

9 pages, 471 KiB  
Communication
TLR2 and TLR4 Polymorphisms Are Not Associated with Dental Caries in Polish Children
by Marta Milona, Tomasz Olszowski, Izabela Uzar, Krzysztof Safranow, Joanna Janiszewska-Olszowska, Monika Szmidt-Kądys, Hubert Rola, Maciej Sikora, Dariusz Chlubek and Grażyna Adler
Int. J. Mol. Sci. 2024, 25(13), 6985; https://doi.org/10.3390/ijms25136985 - 26 Jun 2024
Cited by 1 | Viewed by 967
Abstract
The aim of the present study was to analyze the association of the TLR2 (Toll-like receptor 2 gene) 2258G>A (rs5743708), TLR4 (Toll-like receptor 4 gene) 896A>G (rs4986790), and TLR4 1196C>T (rs4986791) polymorphisms with dental caries in Polish children. The participants, 261 15-year-old children, [...] Read more.
The aim of the present study was to analyze the association of the TLR2 (Toll-like receptor 2 gene) 2258G>A (rs5743708), TLR4 (Toll-like receptor 4 gene) 896A>G (rs4986790), and TLR4 1196C>T (rs4986791) polymorphisms with dental caries in Polish children. The participants, 261 15-year-old children, were divided into two groups: 82 cases (i.e., children with DMFT (Decayed, Missing, and Filled Teeth) index >5, having either moderate or high caries experience, assigned as the “higher” caries experience group) and 179 controls (i.e., children with DMFT ≤ 5, having either low or very low caries experience, assigned as the “lower” caries experience group). Genomic DNA was isolated from buccal swabs, and genotyping was determined by means of real-time PCR (polymerase chain reaction). There were no significant differences in the genotype or allele distributions in all tested SNPs (single nucleotide polymorphisms) between children with “higher” caries experience and those with “lower” caries experience. TLR4 haplotype frequencies did not differ significantly between cases and controls. In an additional analysis with another case definition applied (subjects with DMFT ≥ 1 were assigned as “cases”, whereas children with DMFT = 0 were assigned as “controls”), no significant differences in the TLR2 and TLR4 genotype, allele frequencies, and TLR4 haplotype frequencies were found between the case and the control groups. The results of the present study broaden our knowledge on the potential genetic factors that might affect caries risk and suggest that TLR2 rs5743708 and TLR4 rs4986790 and rs4986791 SNPs are not associated with dental caries susceptibility in Polish children. Full article
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