Nuclear Architecture in Differentiation and Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 28592
Special Issue Editors
Interests: chromosome; telomere; DNA structure; chromatin; epigenetic; ciliates
2. Laboratory of Clinical Molecular Genetics and Epigenetics, Center for Biomedical Education and Research, School of Life Sciences (ZBAF), Faculty of Health, Witten/Herdecke University, 42283 Wuppertal, Germany
Interests: evolution of nuclear architecture; noncoding RNA and histone variants; viral infections and the host cell nucleus
Special Issue Information
Dear Colleagues,
A major challenge of cell biology in the postgenomic era is to understand how the genome is spatiotemporally organized in the 3D/4D nuclear space of eukaryotic cells and how this organization contributes to essential cellular processes such as gene expression, replication, DNA repair or chromosome segregation.
The analysis of the nuclear architecture is a relatively young field of research, which was driven during the last two decades by revolutionary advances in microscopy and deep sequencing technologies. Many features are still under debate, but we are starting to recognize how an impaired nuclear architecture can cause diseases. Thus, developmental programs are resulting in cell-type-specific 3D/4D nuclear organization of cells, which form tissues and organs within the system of the human body. Some instances have been described of how disruptions of these programs can lead to nuclear organization defects, which can be associated with severe developmental disorders. It is the scope of this Special Issue to present the latest insights into the principles of higher order organization of the genome and the epigenome in the cell nucleus from an evolutionary perspective on diverse taxa toward differential 3D/4D nuclear organization in the multiple cell types of complex organisms, such as mammals. This will contribute to our understanding of basic nuclear processes, but importantly also toward the molecular basis of some human diseases as part of a developing systems medicine perspective.
Prof. Dr. Hans J. Lipps
Prof. Dr. Jan Postberg
Guest Editors
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Keywords
- nuclear structure
- epigenetics
- cellular differentiation
- gene expression
- replication
- DNA repair
- disease
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