Synthesis and Functions of Peptides and Peptidomimetics
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".
Deadline for manuscript submissions: 20 September 2024 | Viewed by 4250
Special Issue Editor
Interests: targeted tumor therapy; peptide synthesis; peptide–drug conjugates; GnRH derivatives; combination of drug delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent decades, peptides have received increasing interest in many areas of research; this is due to their high selectivity caused by specific interactions with their targets. There is a broad spectrum in the possible applications of peptides from therapies of illnesses, a part of diagnostic tools, targeting moieties for drug delivery, and the development of hydrogels or other nanoparticles, up to being ingredients in cosmetics. The number of approved peptide-based drugs is continuously increasing, and on average ca. 20 new compounds reach clinical-phase studies, showing the importance of peptides in drug development. Next to the advantages like high specificity and low immunogenicity as well as toxicity, there are some weaknesses of peptides, including a short half-life and fast degradation in human plasma, low oral bioavailability, and, in the case of many short peptides, high conformational flexibility, and therefore low binding affinity. Thus, the main efforts for the development of peptide-based drugs focus on suitable modifications with which to overcome these drawbacks. Substitution with non-native amino acids, cyclization, and using retro-inverso peptides till the development of peptidomimetics all may help to prepare potential drug candidates with not only high efficacy but also higher bioavailability and slower decomposition as well as clearance.
Now we start a new Special Issue in the open access MDPI journal International Journal of Molecular Science, with the title “Synthesis and Functions of Peptides and Peptidomimetics”. We eagerly await review or full papers on the topics mentioned above.
Prof. Dr. Gábor Mező
Guest Editor
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Keywords
- peptides
- peptidomimetics
- peptide-based drugs
- structure optimization
- synthesis