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Special Issue "The Role of Gonadotropin-Releasing Hormone Receptor in Human Diseases"
Deadline for manuscript submissions: 31 December 2019.
Close to the 50th anniversary of the discovery of the hypothalamic decapeptide gonadotropin-releasing hormone (GnRH, also known as LH-RH) by Andrew V. Schally and his co-workers in 1971, we can conclude that GnRH derivatives have become one of the most widely applied peptide based drugs. Several thousands of agonist and antagonist derivatives have been investigated and a dozen of them have been approved as drugs on the market since then. GnRH and its derivatives have influence on many other hormones through the hypothalamus–pituitary–gonadal axis that can be used to cure different hormone dependent cancers, benign prostatic hyperplasia, and uterine fibroids, as well as they be applied in in vitro fertilization. Furthermore, overexpression of GnRH receptors on many tumor types was identified, and thus the direct antitumor effect of GnRH derivatives was detected. In addition, GnRH derivatives as homing devices are in the focus of research related to targeted tumor therapy. In spite of the gathered results, GnRH-related research is still a hot topic in endocrinology and cancer therapy.
This Special Issue “The Role of Gonadotropin-Releasing Hormone Receptor in Human Diseases” aims to provide novel insights into potential therapeutic applications of GnRH derivatives and their drug conjugates, including receptor recognition, signal pathways and mechanism, functional comparison of agonists and antagonists, and the development of new derivatives with improved bioactivity. Authors are invited to submit original research and review articles related to these subjects.
Prof. Gábor Mező
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- GnRH derivatives
- GnRH receptor signaling
- Therapeutic applications
- Drug targeting
- Cancer treatment
- GnRH agonists vs. antagonists
- Homing devices
- Structure–activity relationship