Molecular and Cellular Mechanisms of Myelodysplastic Syndrome
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (30 June 2016) | Viewed by 57275
Special Issue Editors
Interests: myelodysplastic syndrome; hematopoietic stem cells; mouse models; DNA repair
Interests: BCL-2 family; BID; programmed cell death; hematopoiesis; bone marrow failure; DNA damage response; leukemia; apoptosis; biochemistry; cancer; cell cycle; DNA repair; knockout; mass spectroscopy; mouse; phosphorylation; proteomics; signal transduction; stem cells
Special Issue Information
Dear Colleagues,
Myelodysplastic syndrome (MDS) is a group of related, fatal diseases originating in the hematopoietic stem cell (HSC) compartment. It occurs most often in the elderly and in cancer patients after receiving intensive anti-cancer therapy. Since the relative sizes of both of these populations are increasing in many developed countries, MDS is becoming a serious health issue. In fact, based on the Seer database, MDS incidence, at ~75 per 100,000, approaches that of lung cancer. The past 5–10 years of research have led to important discoveries, such as the high prevalence of mutations in known oncogenes and genes encoding components of the RNA processing machinery, as well as the contribution of the HSC microenvironment to the disease development. These recent discoveries shed light on the molecular and cellular mechanisms driving MDS development. The field is now poised to identify better drugs and identify those patients most at risk of developing cancer therapy-related MDS, inspiring hope that improved patient outcomes and personalized chemotherapy to prevent MDS are within reach.
Assoc. Prof. Dr. Vivienne Rebel
Assoc. Prof. Dr. Sandra Zinkel
Guest Editors
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Keywords
- Disease mechanisms
- Hematopoietic stem cells
- Bone marrow microenvironment
- Animal models
- Drug development