Metabolic Bone Diseases: Pathophysiology and Molecular Biology

Dear Colleagues,

Nowadays dramatic demographic changes towards an aging society along with a quiescent lifestyle results in a raised incidence of metabolic diseases worldwide, such as diabetes mellitus type 2. Many of these diseases affect bone metabolism. Indeed, there are more than 70 diseases and health conditions reported causing so-called metabolic bone diseases—characterized by bone pain, altered posture, and poor bone quality (e.g. osteopenia or osteoporosis), and consequently an increased fracture risk. In the case of a fracture, patient-centered care is a great challenge, including fixing the fracture, handling of the surrounding soft tissue and the patients’ mobilization. Despite all the medical progress, these patients often face delayed/impaired bone healing rich in complications.

All this forces society to tackle the existing gaps in the knowledge of metabolic bone disorders. Most metabolic bone diseases have in common an imbalance in osteoblast and osteoclast function, resulting in poor bone quality. However, the mechanisms leading to metabolic bone diseases are far from being elucidated.

This Special Issue will contain a collection of manuscripts that describe investigations into the different stages of bone metabolic diseases, reflecting our current knowledge and describing several diseases and the underlying molecular mechanisms, molecular diagnostics, and novel molecular treatment/therapeutic options.

Prof. Dr. Andreas K. Nüssler
Dr. Sabrina Ehnert
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.