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Recent Research in Magnetic Nanoparticles Engineering, Drug Delivery, and Medical Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Nanoscience".

Deadline for manuscript submissions: closed (30 January 2024) | Viewed by 6341

Special Issue Editor

Dr. Dorota Lachowicz

E-Mail Website
Guest Editor
Academic Centre for Materials and Nanotechnology, AGH University of Science and Technology, Al. A. Mickiewicza 30, 30-059 Krakow, Poland
Interests: drug delivery systems; micro and nanoparticles; nanoparticles; hybrid nanocomposites; magnetic nanoparticles for MRI and magnetic hyperthermia; liposomes; polymeric materials; biopolymers
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The unique magnetic and physicochemical properties of magnetic nanoparticles have made these systems intensively researched for biomedical applications. Magnetic fields can be used to effectively manipulate these precisely engineered smart magnetic materials. Therefore, magnetic nanoparticles are used in targeted drug delivery systems, theranostic platforms, magnetic hyperthermia, MRI imaging, or as a component of tissue engineering scaffolds or coatings of biomaterials/devices. The chemical composition and the morphological structures created by magnetic materials have a significant impact on their toxicity, biocompatibility, and especially their inducible magnetic moment. These nanoparticles can be produced by many methods, from classical chemical, electrochemical, or physical methods to biological syntheses. Magnetic nanoparticle instability in water solutions is a common problem that usually significantly limits their biomedical application. That is why the nanocrystal surface can be further functionalized by creating a stabilizing coating with organic or inorganic molecules, including surfactants, drugs, proteins, enzymes, antibodies, nucleotides, non-ionic detergents, polysaccharides, or other polyelectrolytes.

This Special Issue on “Recent Research in Magnetic Nanoparticles Engineering, Drug Delivery, and Medical Applications” is focused on current trends in modern chemistry, material science, and nanotechnology for the fabrication of magnetic materials for biomedical applications. We invite the submission of original research articles on any topic related to the synthesis, characterization, or application of magnetic materials.

Dr. Dorota Lachowicz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnetic nanoparticles
  • SPIONs
  • drug delivery systems
  • theranostic platforms
  • magnetic hyperthermia
  • MRI imaging
  • tissue engineering
  • regenerative medicine
  • cancer therapy

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Published Papers (3 papers)

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21 pages, 16633 KiB  
Article
Newly Synthesized CoFe2−xDyxO4 (x = 0; 0.1; 0.2; 0.4) Nanoparticles Reveal Promising Anticancer Activity against Melanoma (A375) and Breast Cancer (MCF-7) Cells
by Slaviţa Rotunjanu, Roxana Racoviceanu, Alexandra Mioc, Andreea Milan, Roxana Negrea-Ghiulai, Marius Mioc, Narcisa Laura Marangoci and Codruţa Şoica
Int. J. Mol. Sci. 2023, 24(21), 15733; https://doi.org/10.3390/ijms242115733 - 29 Oct 2023
Cited by 2 | Viewed by 1619
Abstract
The current study focuses on the synthesis via combustion of dysprosium-doped cobalt ferrites that were subsequently physicochemically analyzed in terms of morphological and magnetic properties. Three types of doped nanoparticles were prepared containing different Dy substitutions and coated with HPGCD for higher dispersion [...] Read more.
The current study focuses on the synthesis via combustion of dysprosium-doped cobalt ferrites that were subsequently physicochemically analyzed in terms of morphological and magnetic properties. Three types of doped nanoparticles were prepared containing different Dy substitutions and coated with HPGCD for higher dispersion properties and biocompatibility, and were later submitted to biological tests in order to reveal their potential anticancer utility. Experimental data obtained through FTIR, XRD, SEM and TEM confirmed the inclusion of Dy3+ ions in the nanoparticles’ structure. The size of the newly formed nanoparticles ranged between 20 and 50 nm revealing an inverse proportional relationship with the Dy content. Magnetic studies conducted by VSM indicated a decrease in remanent and saturation mass magnetization, respectively, in Dy-doped nanoparticles in a direct proportionality with the Dy content; the decrease was further amplified by cyclodextrin complexation. Biological assessment in the presence/absence of red light revealed a significant cytotoxic activity in melanoma (A375) and breast (MCF-7) cancer cells, while healthy keratinocytes (HaCaT) remained generally unaffected, thus revealing adequate selectivity. The investigation of the underlying cytotoxic molecular mechanism revealed an apoptotic process as indicated by nuclear fragmentation and shrinkage, as well as by Western blot analysis of caspase 9, p53 and cyclin D1 proteins. The anticancer activity for all doped Co ferrites varied was in a direct correlation to their Dy content but without being affected by the red light irradiation. Full article
(This article belongs to the Special Issue Recent Research in Magnetic Nanoparticles Engineering, Drug Delivery, and Medical Applications)
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13 pages, 3726 KiB  
Article
Magneto-Responsive Textiles for Non-Invasive Heating
by Arkadiusz Józefczak, Katarzyna Kaczmarek, Rafał Bielas, Jitka Procházková and Ivo Šafařík
Int. J. Mol. Sci. 2023, 24(14), 11744; https://doi.org/10.3390/ijms241411744 - 21 Jul 2023
Cited by 2 | Viewed by 1667
Abstract
Magneto-responsive textiles have emerged lately as an important carrier in various fields, including biomedical engineering. To date, most research has been performed on single magnetic fibers and focused mainly on the physical characterization of magnetic textiles. Herein, from simple woven and non-woven textiles [...] Read more.
Magneto-responsive textiles have emerged lately as an important carrier in various fields, including biomedical engineering. To date, most research has been performed on single magnetic fibers and focused mainly on the physical characterization of magnetic textiles. Herein, from simple woven and non-woven textiles we engineered materials with magnetic properties that can become potential candidates for a smart magnetic platform for heating treatments. Experiments were performed on tissue-mimicking materials to test the textiles’ heating efficiency in the site of interest. When the heat was induced with magneto-responsive textiles, the temperature increase in tissue-mimicking phantoms depended on several factors, such as the type of basic textile material, the concentration of magnetic nanoparticles deposited on the textile’s surface, and the number of layers covering the phantom. The values of temperature elevation, achieved with the use of magnetic textiles, are sufficient for potential application in magnetic hyperthermia therapies and as heating patches or bandages. Full article
(This article belongs to the Special Issue Recent Research in Magnetic Nanoparticles Engineering, Drug Delivery, and Medical Applications)
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15 pages, 3070 KiB  
Article
Synthesis of Manganese Zinc Ferrite Nanoparticles in Medical-Grade Silicone for MRI Applications
by Joshua A. Stoll, Dorota Lachowicz, Angelika Kmita, Marta Gajewska, Marcin Sikora, Katarzyna Berent, Marek Przybylski, Stephen E. Russek, Zbigniew J. Celinski and Janusz H. Hankiewicz
Int. J. Mol. Sci. 2023, 24(6), 5685; https://doi.org/10.3390/ijms24065685 - 16 Mar 2023
Cited by 10 | Viewed by 2319
Abstract
The aim of this project is to fabricate hydrogen-rich silicone doped with magnetic nanoparticles for use as a temperature change indicator in magnetic resonance imaging-guided (MRIg) thermal ablations. To avoid clustering, the particles of mixed MnZn ferrite were synthesized directly in a medical-grade [...] Read more.
The aim of this project is to fabricate hydrogen-rich silicone doped with magnetic nanoparticles for use as a temperature change indicator in magnetic resonance imaging-guided (MRIg) thermal ablations. To avoid clustering, the particles of mixed MnZn ferrite were synthesized directly in a medical-grade silicone polymer solution. The particles were characterized by transmission electron microscopy, powder X-ray diffraction, soft X-ray absorption spectroscopy, vibrating sample magnetometry, temperature-dependent nuclear magnetic resonance relaxometry (20 °C to 60 °C, at 3.0 T), and magnetic resonance imaging (at 3.0 T). Synthesized nanoparticles were the size of 4.4 nm ± 2.1 nm and exhibited superparamagnetic behavior. Bulk silicone material showed a good shape stability within the study’s temperature range. Embedded nanoparticles did not influence spin–lattice relaxation, but they shorten the longer component of spin–spin nuclear relaxation times of silicone’s protons. However, these protons exhibited an extremely high r2* relaxivity (above 1200 L s−1 mmol−1) due to the presence of particles, with a moderate decrease in the magnetization with temperature. With an increased temperature decrease of r2*, this ferro–silicone can be potentially used as a temperature indicator in high-temperature MRIg ablations (40 °C to 60 °C). Full article
(This article belongs to the Special Issue Recent Research in Magnetic Nanoparticles Engineering, Drug Delivery, and Medical Applications)
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