Special Issue "Lipid-Protein and Protein-Protein Interactions in Membranes"
Deadline for manuscript submissions: closed (29 February 2020).
Interests: structure/function relationships in membrane proteins: neuroreceptors and ion channels; lipid–protein and protein–protein interactions in biological membranes; potential applications to drug discovery
Interests: structure–function relationship in membrane proteins; lipid–protein interactions; modulation of ion channel structure and function
The application of finer experimental and computational techniques is providing increasing evidence that the structure and function of many membrane proteins are modulated by the surrounding membrane lipids. The mechanisms behind such modulation are diverse and highly complex. For instance, lipid modulation may be exerted directly, through binding of specific lipids to defined binding sites on the membrane protein surface. Alternatively, membrane lipids may segregate domains within the membrane, into which certain proteins partition preferentially or even exclusively and have the chance to find different interacting partners and thus modify their function. The latter is a dynamic process in which changes in lipid composition, such as those found in response to drug treatments or between quiescent and proliferating cellular states, cause a reorganization of membrane domains, a redistribution of membrane proteins, and a drastic change in cellular responses. This makes cellular membranes key players in cell physiology and important pharmacological targets, as there are hundreds of different integral and peripheral membrane proteins involved in the propagation of signals that regulate cell metabolism, proliferation, differentiation or death.
In an attempt to bring together recent advances in this field, José A. Poveda and I will co-edit a Special Issue in the International Journal of Molecular Sciences (IF:4.183) on the topic “Lipid–Protein and Protein–Protein Interactions in Membranes”. We will be delighted if we could have your contribution to this exciting project.
Prof. José Manuel González Ros
Prof. Jose Antonio Poveda Larrosa
Manuscript Submission Information
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