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Special Issue "Lipid-Protein and Protein-Protein Interactions in Membranes"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".

Deadline for manuscript submissions: 29 February 2020.

Special Issue Editors

Prof. José Manuel González Ros
E-Mail Website
Guest Editor
Instituto de Biología Molecular y Celular Universidad Miguel Hernández de Elche Edificio Torregaitán, Elche, Alicante, Spain.
Interests: structure/function relationships in membrane proteins: neuroreceptors and ion channels; lipid–protein and protein–protein interactions in biological membranes; potential applications to drug discovery
Prof. Jose Antonio Poveda Larrosa
E-Mail Website
Co-Guest Editor
Universidad Miguel Hernandez de Elche, Elche, Spain.
Interests: structure–function relationship in membrane proteins; lipid–protein interactions; modulation of ion channel structure and function

Special Issue Information

Dear Colleagues,

The application of finer experimental and computational techniques is providing increasing evidence that the structure and function of many membrane proteins are modulated by the surrounding membrane lipids. The mechanisms behind such modulation are diverse and highly complex. For instance, lipid modulation may be exerted directly, through binding of specific lipids to defined binding sites on the membrane protein surface. Alternatively, membrane lipids may segregate domains within the membrane, into which certain proteins partition preferentially or even exclusively and have the chance to find different interacting partners and thus modify their function. The latter is a dynamic process in which changes in lipid composition, such as those found in response to drug treatments or between quiescent and proliferating cellular states, cause a reorganization of membrane domains, a redistribution of membrane proteins, and a drastic change in cellular responses. This makes cellular membranes key players in cell physiology and important pharmacological targets, as there are hundreds of different integral and peripheral membrane proteins involved in the propagation of signals that regulate cell metabolism, proliferation, differentiation or death.

In an attempt to bring together recent advances in this field, José A. Poveda and I will co-edit a Special Issue in the International Journal of Molecular Sciences (IF:4.183) on the topic “Lipid–Protein and Protein–Protein Interactions in Membranes”. We will be delighted if we could have your contribution to this exciting project.

Prof. José Manuel González Ros
Prof. Jose Antonio Poveda Larrosa
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Open AccessArticle
Effects of Membrane and Biological Target on the Structural and Allosteric Properties of Recoverin: A Computational Approach
Int. J. Mol. Sci. 2019, 20(20), 5009; https://doi.org/10.3390/ijms20205009 - 10 Oct 2019
Recoverin (Rec) is a prototypical calcium sensor protein primarily expressed in the vertebrate retina. The binding of two Ca2+ ions to the functional EF-hand motifs induces the extrusion of a myristoyl group that increases the affinity of Rec for the membrane and [...] Read more.
Recoverin (Rec) is a prototypical calcium sensor protein primarily expressed in the vertebrate retina. The binding of two Ca2+ ions to the functional EF-hand motifs induces the extrusion of a myristoyl group that increases the affinity of Rec for the membrane and leads to the formation of a complex with rhodopsin kinase (GRK1). Here, unbiased all-atom molecular dynamics simulations were performed to monitor the spontaneous insertion of the myristoyl group into a model multicomponent biological membrane for both isolated Rec and for its complex with a peptide from the GRK1 target. It was found that the functional membrane anchoring of the myristoyl group is triggered by persistent electrostatic protein-membrane interactions. In particular, salt bridges between Arg43, Arg46 and polar heads of phosphatidylserine lipids are necessary to enhance the myristoyl hydrophobic packing in the Rec-GRK1 assembly. The long-distance communication between Ca2+-binding EF-hands and residues at the interface with GRK1 is significantly influenced by the presence of the membrane, which leads to dramatic changes in the connectivity of amino acids mediating the highest number of persistent interactions (hubs). In conclusion, specific membrane composition and allosteric interactions are both necessary for the correct assembly and dynamics of functional Rec-GRK1 complex. Full article
(This article belongs to the Special Issue Lipid-Protein and Protein-Protein Interactions in Membranes)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Lipid-Protein and Protein-Protein Interactions in the Pulmonary Surfactant System and their Role in Lung Homeostasis

Authors: Olga Cañadas, Barbara Olmeda and Jesus Perez-Gil

Title: The Role of Protein-Membrane Interactions in Regulating Postsynaptic Function

Authors: Miriam Bell, Christopher T. Lee, and Padmini Rangamani

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