Next Article in Journal
Chromosomal Signatures Corroborate the Phylogenetic Relationships within Akodontini (Rodentia, Sigmodontinae)
Next Article in Special Issue
Modulation of Function, Structure and Clustering of K+ Channels by Lipids: Lessons Learnt from KcsA
Previous Article in Journal
Inhibitory Effective Perturbations of Cilobradine (DK-AH269), A Blocker of HCN Channels, on the Amplitude and Gating of Both Hyperpolarization-Activated Cation and Delayed-Rectifier Potassium Currents
Previous Article in Special Issue
The Implications for Cells of the Lipid Switches Driven by Protein–Membrane Interactions and the Development of Membrane Lipid Therapy
Review

Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis

Institute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Joseph-Stelzmann-Strasse 26, 50931 Cologne, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2412; https://doi.org/10.3390/ijms21072412
Received: 6 March 2020 / Revised: 26 March 2020 / Accepted: 29 March 2020 / Published: 31 March 2020
(This article belongs to the Special Issue Lipid-Protein and Protein-Protein Interactions in Membranes)
Pyroptosis, necroptosis, and ferroptosis are well-characterized forms of regulated necrosis that have been associated with human diseases. During regulated necrosis, plasma membrane damage facilitates the movement of ions and molecules across the bilayer, which finally leads to cell lysis and release of intracellular content. Therefore, these types of cell death have an inflammatory phenotype. Each type of regulated necrosis is mediated by a defined machinery comprising protein and lipid molecules. Here, we discuss how the interaction and reshaping of these cellular components are essential and distinctive processes during pyroptosis, necroptosis, and ferroptosis. We point out that although the plasma membrane is the common target in regulated necrosis, different mechanisms of permeabilization have emerged depending on the cell death form. Pore formation by gasdermins (GSDMs) is a hallmark of pyroptosis, while mixed lineage kinase domain-like (MLKL) protein facilitates membrane permeabilization in necroptosis, and phospholipid peroxidation leads to membrane damage in ferroptosis. This diverse repertoire of mechanisms leading to membrane permeabilization contributes to define the specific inflammatory and immunological outcome of each type of regulated necrosis. Current efforts are focused on new therapies that target critical protein and lipid molecules on these pathways to fight human pathologies associated with inflammation. View Full-Text
Keywords: regulated necrosis; membrane permeabilization; pores; protein-lipid interactions; inflammation regulated necrosis; membrane permeabilization; pores; protein-lipid interactions; inflammation
Show Figures

Figure 1

MDPI and ACS Style

Ros, U.; Pedrera, L.; Garcia-Saez, A.J. Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis. Int. J. Mol. Sci. 2020, 21, 2412. https://doi.org/10.3390/ijms21072412

AMA Style

Ros U, Pedrera L, Garcia-Saez AJ. Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis. International Journal of Molecular Sciences. 2020; 21(7):2412. https://doi.org/10.3390/ijms21072412

Chicago/Turabian Style

Ros, Uris; Pedrera, Lohans; Garcia-Saez, Ana J. 2020. "Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis" Int. J. Mol. Sci. 21, no. 7: 2412. https://doi.org/10.3390/ijms21072412

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop