Special Issue "Genome Organization in Interphase Chromosomes"
Deadline for manuscript submissions: 31 July 2021.
Interphase chromosomes are the structures where the eukaryotic genome is expressed. Polytene interphase chromosomes demonstrate a characteristic banding pattern of black and gray bands and light interbands. These patterns are the same in both types of chromosomes—in polytene and in cell culture interphase. Genes of development are located within the black bands, while housekeeping genes occupy two structures—that is, interbands (promoter sites) and gray bands (sites of gene bodies), and origins of replication are located predominantly in the interbands. These three types of genes correspond to the their own chromatin states, gene sets, nucleosome modifiers, chromatin remodelers, and protein complexes of transcription enhancers. On the other hand, heterochromatin is an essential part of eukaryotic genomes. It plays important roles in genome stability, transcriptional modification, and chromosome organization.
The aim of this Special Issue "Genome Organization in Interphase Chromosomes " is to consider contemporary data on the full-genome analysis of the genetic organization of chromosome structures, nucleosome distribution, further characterization of chromatin states in different chromatin models, relations of chromatin states with genes, protein complexes regulating transcription and replication in the genome, protein complexes regulating chromatin remodeling, the ability of enhancers to stimulate promoters over long distances and enhancer–promoter interactions only within such domains, as well as the relationship of topologically associated domains (TADs) with chromosome structures and gene/protein complexes.
This review critically examines the current understanding of heterochromatin structure, repetitive DNA, and our understanding of heterochromatin’s evolution and function.
Prof. Dr. Igor Zhimulev
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Interphase chromosomes
- chromatin states
- houskeeping genes
- genes of development
- hetrochromatic part of genome
- gene promoters
- genome domains
- DNA-proteins complexes