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Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes

Department of the Control of Genetic Processes, Institute of Gene Biology Russian Academy of Sciences, 34/5 Vavilov St., 119334 Moscow, Russia
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Int. J. Mol. Sci. 2021, 22(2), 671; https://doi.org/10.3390/ijms22020671
Received: 7 December 2020 / Revised: 28 December 2020 / Accepted: 9 January 2021 / Published: 12 January 2021
(This article belongs to the Special Issue Genome Organization in Interphase Chromosomes)
In higher eukaryotes, enhancers determine the activation of developmental gene transcription in specific cell types and stages of embryogenesis. Enhancers transform the signals produced by various transcription factors within a given cell, activating the transcription of the targeted genes. Often, developmental genes can be associated with dozens of enhancers, some of which are located at large distances from the promoters that they regulate. Currently, the mechanisms underlying specific distance interactions between enhancers and promoters remain poorly understood. This review briefly describes the properties of enhancers and discusses the mechanisms of distance interactions and potential proteins involved in this process. View Full-Text
Keywords: C2H2 proteins; CTCF; LDB1; chromatin insulator; long-distance interactions C2H2 proteins; CTCF; LDB1; chromatin insulator; long-distance interactions
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MDPI and ACS Style

Kyrchanova, O.; Georgiev, P. Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes. Int. J. Mol. Sci. 2021, 22, 671. https://doi.org/10.3390/ijms22020671

AMA Style

Kyrchanova O, Georgiev P. Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes. International Journal of Molecular Sciences. 2021; 22(2):671. https://doi.org/10.3390/ijms22020671

Chicago/Turabian Style

Kyrchanova, Olga; Georgiev, Pavel. 2021. "Mechanisms of Enhancer-Promoter Interactions in Higher Eukaryotes" Int. J. Mol. Sci. 22, no. 2: 671. https://doi.org/10.3390/ijms22020671

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