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The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture

Department of Molecular Genetics of Cell, Institute of Molecular Genetics of National Research Centre “Kurchatov Institute”, 123182 Moscow, Russia
Int. J. Mol. Sci. 2020, 21(24), 9475; https://doi.org/10.3390/ijms21249475
Received: 29 November 2020 / Revised: 10 December 2020 / Accepted: 11 December 2020 / Published: 13 December 2020
(This article belongs to the Special Issue Genome Organization in Interphase Chromosomes)
For a long time, the nuclear lamina was thought to be the sole scaffold for the attachment of chromosomes to the nuclear envelope (NE) in metazoans. However, accumulating evidence indicates that nuclear pore complexes (NPCs) comprised of nucleoporins (Nups) participate in this process as well. One of the Nups, Elys, initiates NPC reassembly at the end of mitosis. Elys directly binds the decondensing chromatin and interacts with the Nup107–160 subcomplex of NPCs, thus serving as a seeding point for the subsequent recruitment of other NPC subcomplexes and connecting chromatin with the re-forming NE. Recent studies also uncovered the important functions of Elys during interphase where it interacts with chromatin and affects its compactness. Therefore, Elys seems to be one of the key Nups regulating chromatin organization. This review summarizes the current state of our knowledge about the participation of Elys in the post-mitotic NPC reassembly as well as the role that Elys and other Nups play in the maintenance of genome architecture. View Full-Text
Keywords: nucleoporin; Elys; Mel-28; NPC; nuclear envelope; genome architecture; chromatin nucleoporin; Elys; Mel-28; NPC; nuclear envelope; genome architecture; chromatin
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MDPI and ACS Style

Shevelyov, Y.Y. The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture. Int. J. Mol. Sci. 2020, 21, 9475. https://doi.org/10.3390/ijms21249475

AMA Style

Shevelyov YY. The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture. International Journal of Molecular Sciences. 2020; 21(24):9475. https://doi.org/10.3390/ijms21249475

Chicago/Turabian Style

Shevelyov, Yuri Y. 2020. "The Role of Nucleoporin Elys in Nuclear Pore Complex Assembly and Regulation of Genome Architecture" Int. J. Mol. Sci. 21, no. 24: 9475. https://doi.org/10.3390/ijms21249475

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