Special Issue "Epigenetics in Metabolic and Neurological Disorders"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (22 December 2019).
Interests: medical genetics; genetics and epigenetics of human reproduction; stem cells
Special Issues and Collections in MDPI journals
Epigenetics is a gene regulation mechanism based on chemical modifications of genomic DNA and histone proteins, as well as to the production of miRNA. Epigenetic alterations can cause congenital disorders, including genomic imprinting disorders, X-chromosome inactivation disorders and epigenetic regulation-associated molecule disorders. However, it has been recently suggested that epigenetic mechanisms could be also related to an increased susceptibility to metabolic and neurological disorders throughout lifetime.
Epigenetic modifications in DNA are vulnerable to environmental stress, such as malnutrition, environmental chemicals and mental stress, mostly occurring during the early period of life, but also during prenatal life and even during maternal and paternal gametogenesis.
Since the epigenome has a reversible property, induced epigenomic alterations can be potentially restored, leading to the possibility of an epigenomic-based preemptive medicine consisting of early detection of epigenomic signatures and early intervention.
In this Special Issue, I would like to invite review and original articles that focus on the epigenetic basis of the susceptibility of metabolic and neurological diseases in the frame of preventive strategies involving early life, prenatal life and periconceptional life.
Prof. Dr. Liborio Stuppia
Manuscript Submission Information
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