MicroRNA and Non-coding RNA: From Basic Research to Potential Clinical Application

Dear Colleagues,

Out of the central dogma of molecular biology, messenger RNA (mRNA) is translated into protein. The transcriptome biochemical machinery relies on noncoding RNA (ncRNAs), which, unlike mRNA, is not translated into protein. Such ncRNAs comprise over 80% of the transcriptome by mass and are linked to a growing list of functional roles in human physiology, biology, biochemistry, and disease. RNA modulation has become a promising therapeutic approach for the treatment of several types of disease. The emerging field of noncoding RNA-based biomarkers and/or therapies has now come to the attention of several fields of application, in which it could provide valuable advancements compared to current clinical biochemistry and pharmacological treatment, such as small-molecule drugs or antibodies. Microarray technology and the advent of next-generation sequencing (NGS) have significantly broadened our understanding of ncRNAs in recent decades and introduced new opportunities for clinical applications.

The Special Issue is guest edited by Prof. Dr. Erika Cione, with the assistance of Dr. Diana Marisol Abrego Guandique (University of Magna Graecia-Catanzaro). We would like to gather the recent advances in this field, and we are delighted to invite you to contribute.

Prof. Dr. Erika Cione
Guest Editor

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• miRNA
• ncRNA
• biomarkers
• therapeutics
• microarray
• NGS