Special Issue "DNA or RNA-Mediated Innate Immune Response"
Deadline for manuscript submissions: 30 December 2020.
Interests: HIV, viral fitness, innat immunity, non-coding RNA, autophage, Interleukin-27, Interferon lambda-1, Reactive Oxygen Specises Webpage: https://david.ncifcrf.gov
Interests: all forms of RNA or DNA, including siRNA, miRNA, long non-coding RNA, DNA virus pathengen-induced Interferons and inflammatory cytokines, especially the mechanism of type III interferon inducing pathway
Innate immunity is the first line of defense and relies on germline-encoded pattern recognition receptors (PRRs) that primarily recognize conserved microbial molecules termed pathogen-associated molecular patterns (PAMPs). It has been known for over a decade that DNA or RNA, the most recognizable unit of life, is a potent trigger of induction interferons and proinflammatory cytokines in cells. Nucleic acids and their derivatives are one of the most important groups of PAMPs, particularly in the innate immune response against viruses. Research in the last decade has led to the identification and characterization of an increasing number of extracellular and intracellular PRRs. Two main classes of PRRs have been described in mammalian cells: membrane-bound receptors, such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), and cytoplasmic sensors, including NOD-like receptors (NLRs), pyrin and HIN domain-containing (PYHIN) family members, RIG-I-like receptors (RLRs), and an increasing range of cytosolic nucleic acid sensors. However, how a new pathogen is recognized and how innate immune responses are initiated in different tissues or cells remain case-by-case questions. In turn, viruses have strategies to escape from the innate immure response by suppressing the signal pathway involved in the immune responses.
This Special Issue “DNA or RNA-Mediated Innate Immune Response” will cover a selection of original research articles, short communications, and current review articles in all areas of DNA or RNA-mediated innate immunity.
Dr. Tomozumi Imamichi
Dr. Hongyan Sui
Manuscript Submission Information
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- innate immunity
- inflammatory cytokines
- pattern recognition receptors (PRRs)
- pathogen-associated molecular patterns (PAMPs)