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Special Issue "DNA or RNA-Mediated Innate Immune Response"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".

Deadline for manuscript submissions: 30 December 2020.

Special Issue Editors

Dr. Tomozumi Imamichi
Guest Editor
Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA
Interests: HIV, viral fitness, innat immunity, non-coding RNA, autophage, Interleukin-27, Interferon lambda-1, Reactive Oxygen Specises Webpage: https://david.ncifcrf.gov
Dr. Hongyan Sui

Guest Editor
Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA
Interests: all forms of RNA or DNA, including siRNA, miRNA, long non-coding RNA, DNA virus pathengen-induced Interferons and inflammatory cytokines, especially the mechanism of type III interferon inducing pathway

Special Issue Information

Dear Colleagues,

Innate immunity is the first line of defense and relies on germline-encoded pattern recognition receptors (PRRs) that primarily recognize conserved microbial molecules termed pathogen-associated molecular patterns (PAMPs). It has been known for over a decade that DNA or RNA, the most recognizable unit of life, is a potent trigger of induction interferons and proinflammatory cytokines in cells. Nucleic acids and their derivatives are one of the most important groups of PAMPs, particularly in the innate immune response against viruses. Research in the last decade has led to the identification and characterization of an increasing number of extracellular and intracellular PRRs. Two main classes of PRRs have been described in mammalian cells: membrane-bound receptors, such as Toll-like receptors (TLRs) and C-type lectin receptors (CLRs), and cytoplasmic sensors, including NOD-like receptors (NLRs), pyrin and HIN domain-containing (PYHIN) family members, RIG-I-like receptors (RLRs), and an increasing range of cytosolic nucleic acid sensors. However, how a new pathogen is recognized and how innate immune responses are initiated in different tissues or cells remain case-by-case questions. In turn, viruses have strategies to escape from the innate immure response by suppressing the signal pathway involved in the immune responses.

This Special Issue “DNA or RNA-Mediated Innate Immune Response” will cover a selection of original research articles, short communications, and current review articles in all areas of DNA or RNA-mediated innate immunity.

Dr. Tomozumi Imamichi
Dr. Hongyan Sui
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • innate immunity
  • interferons
  • inflammatory cytokines
  • pattern recognition receptors (PRRs)
  • pathogen-associated molecular patterns (PAMPs)

Published Papers

This special issue is now open for submission.
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