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A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs

by 1 and 1,2,*
1
Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
2
Shanghai Key Laboratory of Bioactive Small Molecules, State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
*
Author to whom correspondence should be addressed.
Academic Editors: Tomozumi Imamichi and Hongyan Sui
Int. J. Mol. Sci. 2021, 22(17), 9535; https://doi.org/10.3390/ijms22179535
Received: 1 August 2021 / Revised: 30 August 2021 / Accepted: 31 August 2021 / Published: 2 September 2021
(This article belongs to the Special Issue DNA or RNA-Mediated Innate Immune Response)
Long non-coding RNAs (lncRNAs) represent crucial transcriptional and post-transcriptional gene regulators during antimicrobial responses in the host innate immune system. Studies have shown that lncRNAs are expressed in a highly tissue- and cell-specific- manner and are involved in the differentiation and function of innate immune cells, as well as inflammatory and antiviral processes, through versatile molecular mechanisms. These lncRNAs function via the interactions with DNA, RNA, or protein in either cis or trans pattern, relying on their specific sequences or their transcriptions and processing. The dysregulation of lncRNA function is associated with various human non-infectious diseases, such as inflammatory bowel disease, cardiovascular diseases, and diabetes mellitus. Here, we provide an overview of the regulation and mechanisms of lncRNA function in the development and differentiation of innate immune cells, and during the activation or repression of innate immune responses. These elucidations might be beneficial for the development of therapeutic strategies targeting inflammatory and innate immune-mediated diseases. View Full-Text
Keywords: long non-coding RNA; transcriptional regulation; inflammation; innate immunity; innate immune cells long non-coding RNA; transcriptional regulation; inflammation; innate immunity; innate immune cells
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MDPI and ACS Style

Xie, Y.; Wei, Y. A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs. Int. J. Mol. Sci. 2021, 22, 9535. https://doi.org/10.3390/ijms22179535

AMA Style

Xie Y, Wei Y. A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs. International Journal of Molecular Sciences. 2021; 22(17):9535. https://doi.org/10.3390/ijms22179535

Chicago/Turabian Style

Xie, Yuhuai, and Yuanyuan Wei. 2021. "A Novel Regulatory Player in the Innate Immune System: Long Non-Coding RNAs" International Journal of Molecular Sciences 22, no. 17: 9535. https://doi.org/10.3390/ijms22179535

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