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Role of Post-Translational Modifications of cGAS in Innate Immunity

by and *
Department of Microbiology and Immunology, Tulane University, New Orleans, LA 70118, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 7842; https://doi.org/10.3390/ijms21217842
Received: 29 September 2020 / Revised: 18 October 2020 / Accepted: 20 October 2020 / Published: 22 October 2020
(This article belongs to the Special Issue DNA or RNA-Mediated Innate Immune Response)
Cyclic GMP–AMP synthase (cGAS) is the synthase that generates the second messenger cyclic GMP–AMP (cGAMP) upon DNA binding. cGAS was first discovered as the cytosolic DNA sensor that detects DNA exposed in the cytoplasm either from pathogens or cellular damage. Activated cGAS instigates the signaling cascades to activate type I interferon (IFN) expression, critical for host defense and autoimmune diseases. In addition, cGAS plays a role in senescence, DNA repair, apoptosis, and tumorigenesis. Recently, various post-translational modifications (PTMs) of cGAS have been reported, such as phosphorylation, ubiquitination, acetylation, glutamylation, and sumoylation. These PTMs profoundly affect cGAS functions. Thus, here we review the recent reported PTMs of cGAS and how these PTMs regulate cGAS enzymatic activity, DNA binding, and protein stability, and discuss the potential future directions. View Full-Text
Keywords: cGAS; innate immunity; post-translational modification; phosphorylation; ubiquitination; acetylation; glutamylation; sumoylation cGAS; innate immunity; post-translational modification; phosphorylation; ubiquitination; acetylation; glutamylation; sumoylation
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MDPI and ACS Style

Wu, Y.; Li, S. Role of Post-Translational Modifications of cGAS in Innate Immunity. Int. J. Mol. Sci. 2020, 21, 7842. https://doi.org/10.3390/ijms21217842

AMA Style

Wu Y, Li S. Role of Post-Translational Modifications of cGAS in Innate Immunity. International Journal of Molecular Sciences. 2020; 21(21):7842. https://doi.org/10.3390/ijms21217842

Chicago/Turabian Style

Wu, Yakun, and Shitao Li. 2020. "Role of Post-Translational Modifications of cGAS in Innate Immunity" International Journal of Molecular Sciences 21, no. 21: 7842. https://doi.org/10.3390/ijms21217842

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