Special Issue "The Future of Cartilage Repair in Complex Biological Situations"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2020).
Interests: cartilage; chondrocyte; degeneration; cell therapy; early diagnosis; spatial organization; biomechanics; mechanobiology; cell morphology; biophsical stimuli
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The clinical repair of focal articular cartilage defects is currently based on established surgical procedures and evidence-based guidelines that are optimized to specific defect characteristics and co-morbidities. However, effective repair strategies remain a major challenge in complex biochemical and biophysical environments associated with progressive degeneration, inflammation, and structural alterations of both articular cartilage and functionally-associated joint tissues; for example, early processes that lead to primary and/or secondary osteoarthritis (OA) such as post-traumatic OA. The second challenge is to develop future cartilage repair strategies in such a way that the principles of molecular, cellular, tissue, and joint functions are able to control their surrounding environment with a sufficiently complex design, but also that both the combined components as well as the individual components will remain licensable, given the current regulatory and financial framework. As the available tools for detecting early disease vs. progressive disease may not be sensitive enough to diagnose the disease at an early stage, the third challenge is to diagnostically pinpoint the best timing for detecting early disease to enable early intervention. Overcoming this will aid us in identifying the optimal stage of disease progression for the successful application of future cartilage and joint repair strategies.
In the context of developing future articular cartilage repair strategies, this Special Issue’s Editor invites original contributions and review articles that address these challenges. The suggested focus is to describe, control, and/or assess the articular cartilage environment on the molecular level but also on the associated cellular, tissue, joint, and/or systemic levels in order to make a significant contribution towards the future of cartilage repair in complex situations.
Prof. Dr. Bernd Rolauffs
Manuscript Submission Information
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