Special Issue "Bone Substitute Material"
Deadline for manuscript submissions: closed (31 March 2021).
Critical size bone defects still remain challenging in orthopedic and trauma surgery. Typical examples are bone loss caused by limb-preserving musculoskeletal tumor operations, trauma-associated bone destruction or bone loss due to implant-related complication such as periprosthetic loosening or infection. Moreover, the demographics in many countries of the Western world have shown an increase in the populations of elderly people, which demands special treatment concepts for the osteoporotic bone. Here, bone substitute materials are promising candidates to bridge bone defects. They can act as scaffold for the local tissue, allowing bone regeneration (osteoconduction), may promote local bone formation (osteopromotion) or induct bone regeneration (osteoinduction). Here, both cell–material interactions and material properties determine the further healing. Therefore, strong efforts have been made to design and compose innovative bone substitute materials qualified for bone regeneration. Surface modifications, nanotechnology, and in silico models present innovative inputs. There is evidence that interdisciplinary approaches including combination with biologicals such as cytokines, growth factors or cell-therapeutics will revolutionize the application of existing bone substitute materials. However, due to legal restrictions, the clinical application of these materials is restricted. This edition presents the latest research results and future perspectives in bone substitute material research.
Prof. Dr. Marcus Jäger
Manuscript Submission Information
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- bone substitutes
- bone defects