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Special Issue "Bone Substitute Material"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Macromolecules".

Deadline for manuscript submissions: closed (31 March 2021).

Special Issue Editor

Prof. Dr. Marcus Jäger
E-Mail Website
Guest Editor
Universität Duisburg-Essen, Essen, Germany
Interests: innovative materials (bone substitute materials, biometals, ceramics, auto- and allografts); bone and cartilage regeneration and the diagnosis and therapy of osteonecrosis

Special Issue Information

Dear Colleagues,

Critical size bone defects still remain challenging in orthopedic and trauma surgery. Typical examples are bone loss caused by limb-preserving musculoskeletal tumor operations, trauma-associated bone destruction or bone loss due to implant-related complication such as periprosthetic loosening or infection. Moreover, the demographics in many countries of the Western world have shown an increase in the populations of elderly people, which demands special treatment concepts for the osteoporotic bone. Here, bone substitute materials are promising candidates to bridge bone defects. They can act as scaffold for the local tissue, allowing bone regeneration (osteoconduction), may promote local bone formation (osteopromotion) or induct bone regeneration (osteoinduction). Here, both cell–material interactions and material properties determine the further healing. Therefore, strong efforts have been made to design and compose innovative bone substitute materials qualified for bone regeneration. Surface modifications, nanotechnology, and in silico models present innovative inputs. There is evidence that interdisciplinary approaches including combination with biologicals such as cytokines, growth factors or cell-therapeutics will revolutionize the application of existing bone substitute materials. However, due to legal restrictions, the clinical application of these materials is restricted. This edition presents the latest research results and future perspectives in bone substitute material research.

Prof. Dr. Marcus Jäger
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • bone substitutes
  • biomaterials
  • bone defects
  • regeneration
  • ceramics
  • scaffolds

Published Papers (1 paper)

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Open AccessReview
Role of Scaffolds, Subchondral, Intra-Articular Injections of Fresh Autologous Bone Marrow Concentrate Regenerative Cells in Treating Human Knee Cartilage Lesions: Different Approaches and Different Results
Int. J. Mol. Sci. 2021, 22(8), 3844; https://doi.org/10.3390/ijms22083844 - 08 Apr 2021
Viewed by 254
The value of bone marrow aspirate concentrates for treatment of human knee cartilage lesions is unclear. Most of the studies were performed with intra-articular injections. However, subchondral bone plays an important role in the progression of osteoarthritis. We investigated by a literature review [...] Read more.
The value of bone marrow aspirate concentrates for treatment of human knee cartilage lesions is unclear. Most of the studies were performed with intra-articular injections. However, subchondral bone plays an important role in the progression of osteoarthritis. We investigated by a literature review whether joint, subchondral bone, or/and scaffolds implantation of fresh autologous bone marrow aspirate concentrated (BMAC) containing mesenchymal stem cells (MSCs) would improve osteoarthritis (OA). There is in vivo evidence that suggests that all these different approaches (intra-articular injections, subchondral implantation, scaffolds loaded with BMAC) can improve the patient. This review analyzes the evidence for each different approach to treat OA. We found that the use of intra-articular injections resulted in a significant relief of pain symptoms in the short term and was maintained in 12 months. However, the clinical trials indicate that the application of autologous bone marrow concentrates in combination with scaffolds or in injection in the subchondral bone was superior to intra-articular injection for long-term results. The tendency of MSCs to differentiate into fibrocartilage affecting the outcome was a common issue faced by all the studies when biopsies were performed, except for scaffolds implantation in which some hyaline cartilage was found. The review suggests also that both implantation of subchondral BMAC and scaffolds loaded with BMAC could reduce the need for further surgery. Full article
(This article belongs to the Special Issue Bone Substitute Material)
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