Contribution of Endothelial Dysfunction to Neurovascular and Cardiovascular Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (20 August 2024) | Viewed by 8796
Special Issue Editor
2. Department of Neurosurgery, University Hospital Helsinki, Topeliuksenkatu 5, 00260 Helsinki, Finland
Interests: intracranial aneurysm; arteriovenous malformation; subarachnoid hemorrhage; endothelial dysfunction; inflammation; senescence; inflammaging
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Special Issue Information
Dear Colleagues,
Endothelial cells line the inner layer of all blood vessels. These are the first cell type in vessels, which come in contact with all kinds of noxious stimuli, including hypertension, hemodynamic shear stress, increased alcohol levels, and the constituents of smoking in blood, resulting in endothelial cell activation, dysfunction, and senescence. The activated endothelial cells increase the expression and release of inflammatory cytokines, chemokines, cell adhesion molecules, and matrix metalloproteinases that consequently induce tissue remodeling and promote the migration and infiltration of inflammatory cells. This creates a local inflammatory microenvironment, which finally leads to the initiation and progression of neurovascular and cardiovascular diseases.
Contributions to this Special Issue will provide insight into the mechanisms through which endothelial cell activation contributes to the pathogenesis of vascular complications and diseases. A better understanding of these mechanisms would provide an opportunity to prevent and treat vascular disorders triggered and advanced by endothelial dysfunction.
Topics of interest to this Special Issue include but are not limited to:
- Mechanism of endothelial cell dysfunction;
- Mediators of endothelial dysfunction;
- Endothelial cells as a target for drug therapy;
- Senescence of endothelial cells/senolysis of endothelial cells;
- The senescence-associated secretory phenotype of endothelial cells;
- Endothelial inflammaging;
- Structural remodeling of the artery wall;
- Activation of Nf-κB, MAPKs, and mTOR pathways in endothelial cells;
- The effect of acquired risk factors (smoking, alcohol abuse, obesity, etc.) on endothelial cells;
- The effect of oxidative stress on endothelial cells;
- Crosstalk between activated/dysfunctional endothelial cells and other cell types, e.g., smooth muscle cells and inflammatory cells.
This Special Issue is supervised by Dr. Sajjad Muhammad and assisted by our Topical Advisory Panel Member Dr. Dilaware Khan (Heinrich-Heine-Universität Düsseldorf).
Dr. Sajjad Muhammad
Guest Editor
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Keywords
- endothelial dysfunction
- endothelial cell senescence
- endothelial cell senolysis
- senescence-associated secretory phenotype
- matrix metalloproteinases
- inflammation
- inflammaging
- Nf-κB
- MAPKs
- mTOR pathway
- vascular disorders
- alcohol abuse
- smoking
- hypertension
- shear stress
- oxidative stress
- cardiovascular diseases
- neurovascular diseases
- cardiovascular pathophysiology
- neurovascular pathophysiology
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