Special Issue "Role of the Extracellular Vesicles in Obesity and Related Diseases"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2021).
Interests: Obesity, adipose tissue, type 2 diabetes, adipokines, proteomics, secretomes, extracellular vesicles, biomarkers
Interests: Biomarkers, genetics, genomics, epigenetics, non-coding RNAs, adipocytes, hepatocytes, adipose tissue, liver, metabolism, fatty acid homeostasis, obesity, type 2 diabetes, non-alcoholic fatty liver disease
In the last decade, extracellular vesicles (EVs) have arisen as a complex and very specialized mechanism for cell-to-cell crosstalk at the local (autocrine and paracrine signal) and distant level (endocrine system of communication). EVs comprise spherical lipovesicles, namely exosomes, microvesicles and apoptotic bodies of diverse sizes (up to 1,000 nm) and different origins, released by multiple cells responding to stimuli. EVs can be found in body fluids and in cell culture media, and enclose membrane and cytosolic components, such as proteins, lipids and many RNAs, including microRNAs and other non-coding RNA species with regulatory properties. This composition is conditioned by the site of biogenesis and the physiological response of cells, which may spread the signal along body tissues through this fine-tuned system of communication. In particular, exosomes have been recently rediscovered due to its ability as a sophisticated intercellular communicating system that implies interaction and fusion to liberate their molecular content in the cytoplasm of hosting cells. Then, exosomes impact commitment of target cells, inducing significant changes that may lead their contribution in different physiological processes. Also of key interest, since these vesicles and their molecular cargo may mirror physio-pathological conditions, EVs and their content have arisen as potential biomarkers of diagnosis and prognosis value. All these attributes have generated great expectations around EVs, making the study of these vehicles a hot topic in many fields of research.
Nowadays, the role of EVs on cell communication relevant to the development of metabolic diseases is still poorly known. There is increasing evidence regarding the implication of circulating EVs in obesity-associated metabolic deregulation. Indeed, EVs shed by an hyperplasic adipose tissue have been demonstrated to be involved in adipocyte/macrophage crosstalk, and also to impact insulin signalling and gene expression in muscle and liver, contributing to the development of metabolic disturbances related to obesity. In addition, the synthesis and release of microRNAs loaded in EVs by adipocytes and activated macrophages found in obese fat depots make them attractive candidate biomarkers for obesity and associated diseases.
We invite researchers to contribute either with original research or review articles focusing on every aspect regarding the role and function of EVs shed by adipose tissue in healthy and pathological conditions including the onset and progression of obesity and its comorbidities.
Dr. María Pardo Pérez
Dr. Francisco Jose Ortega
Manuscript Submission Information
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- Extracellular vesicles
- Adipose tissue
- Cell communication