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Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity

1
Grupo Obesidómica, Área de Endocrinología, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain
2
Grupo Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago (IDIS), Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain
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CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, 15706 Santiago de Compostela, Spain
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Servicio de Cirugía Plástica y Reparadora, Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain
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Servicio de Cirugía General, Xerencia de Xestión Integrada de Santiago (XXIS/SERGAS), 15706 Santiago de Compostela, Spain
*
Author to whom correspondence should be addressed.
Both authors participated equally on this manuscript.
Int. J. Mol. Sci. 2020, 21(24), 9366; https://doi.org/10.3390/ijms21249366
Received: 2 November 2020 / Revised: 3 December 2020 / Accepted: 4 December 2020 / Published: 9 December 2020
(This article belongs to the Special Issue Role of the Extracellular Vesicles in Obesity and Related Diseases)
The extracellular vesicles (EVs) have emerged as key players in metabolic disorders rising as an alternative way of paracrine/endocrine communication. In particular, in relation to adipose tissue (AT) secreted EVs, the current knowledge about its composition and function is still very limited. Nevertheless, those vesicles have been lately suggested as key players in AT communication at local level, and also with other metabolic peripheral and central organs participating in physiological homoeostasis, and also contributing to the metabolic deregulation related to obesity, diabetes, and associated comorbidities. The aim of this review is to summarize the most relevant data around the EVs secreted by adipose tissue, and especially in the context of obesity, focusing in its protein cargo. The description of the most frequent proteins identified in EVs shed by AT and its components, including their changes under pathological status, will give the reader a whole picture about the membrane/antigens, and intracellular proteins known so far, in an attempt to elucidate functional roles, and also suggesting biomarkers and new paths of therapeutic action. View Full-Text
Keywords: adipose tissue; extracellular vesicles; exosomes; obesity; biomarkers adipose tissue; extracellular vesicles; exosomes; obesity; biomarkers
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MDPI and ACS Style

Camino, T.; Lago-Baameiro, N.; Martis-Sueiro, A.; Couto, I.; Santos, F.; Baltar, J.; Pardo, M. Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity. Int. J. Mol. Sci. 2020, 21, 9366. https://doi.org/10.3390/ijms21249366

AMA Style

Camino T, Lago-Baameiro N, Martis-Sueiro A, Couto I, Santos F, Baltar J, Pardo M. Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity. International Journal of Molecular Sciences. 2020; 21(24):9366. https://doi.org/10.3390/ijms21249366

Chicago/Turabian Style

Camino, Tamara; Lago-Baameiro, Nerea; Martis-Sueiro, Aurelio; Couto, Iván; Santos, Francisco; Baltar, Javier; Pardo, María. 2020. "Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity" Int. J. Mol. Sci. 21, no. 24: 9366. https://doi.org/10.3390/ijms21249366

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