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Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity

Adipocyte-Derived Extracellular Vesicles: State of the Art

by 1,2,*, 3,4 and 3,4,*
CarMeN Laboratory, INSERM/1060- INRAE/1397, University of Lyon, Lyon-Sud Faculty of Medicine, 69310 Pierre Benite, France
Institute of Functional Genomic of Lyon (IGFL), ENS, CNRS UMR 5242, University of Lyon, 69364 Lyon, France
Université de Nantes, CNRS, INSERM, L’Institut du Thorax, F-44000 Nantes, France
Univ Angers, SFR ICAT, F-49000 Angers, France
Authors to whom correspondence should be addressed.
Academic Editor: María Pardo Pérez
Int. J. Mol. Sci. 2021, 22(4), 1788;
Received: 15 January 2021 / Revised: 6 February 2021 / Accepted: 8 February 2021 / Published: 11 February 2021
(This article belongs to the Special Issue Role of the Extracellular Vesicles in Obesity and Related Diseases)
White adipose tissue (WAT) is involved in long-term energy storage and represents 10–15% of total body weight in healthy humans. WAT secretes many peptides (adipokines), hormones and steroids involved in its homeostatic role, especially in carbohydrate–lipid metabolism regulation. Recently, adipocyte-derived extracellular vesicles (AdEVs) have been highlighted as important actors of intercellular communication that participate in metabolic responses to control energy flux and immune response. In this review, we focus on the role of AdEVs in the cross-talks between the different cellular types composing WAT with regard to their contribution to WAT homeostasis and metabolic complications development. We also discuss the AdEV cargoes (proteins, lipids, RNAs) which may explain AdEV’s biological effects and demonstrate that, in terms of proteins, AdEV has a very specific signature. Finally, we list and suggest potential therapeutic strategies to modulate AdEV release and composition in order to reduce their deleterious effects during the development of metabolic complications associated with obesity. View Full-Text
Keywords: adipocytes; extracellular vesicles; exosomes; obesity; diabetes; therapy adipocytes; extracellular vesicles; exosomes; obesity; diabetes; therapy
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MDPI and ACS Style

Rome, S.; Blandin, A.; Le Lay, S. Adipocyte-Derived Extracellular Vesicles: State of the Art. Int. J. Mol. Sci. 2021, 22, 1788.

AMA Style

Rome S, Blandin A, Le Lay S. Adipocyte-Derived Extracellular Vesicles: State of the Art. International Journal of Molecular Sciences. 2021; 22(4):1788.

Chicago/Turabian Style

Rome, Sophie, Alexia Blandin, and Soazig Le Lay. 2021. "Adipocyte-Derived Extracellular Vesicles: State of the Art" International Journal of Molecular Sciences 22, no. 4: 1788.

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