Oral Microbiota in Health and Disease: Novel Insights and Therapeutic Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 September 2025 | Viewed by 15
Special Issue Editor
Interests: periodontology; oral implantology; tissue regeneration; bone regeneration; oral surgery; microbiota; microbiome; biomedicine
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The oral microbiome represents one of the most diverse and dynamic microbial communities in the human body, playing pivotal roles in both maintaining oral health and contributing to oral diseases. This Special Issue will expand our understanding of the complex interactions between oral microorganisms and host tissues, with a particular emphasis on molecular mechanisms and emerging therapeutic approaches. Recent advances in sequencing technologies and bioinformatic analyses have revolutionized our understanding of oral microbial communities, revealing intricate ecological networks that influence periodontal health, caries development, oral mucosal integrity, and even systemic conditions. The identification of keystone pathogens, beneficial commensals, and their bioactive metabolites has opened new avenues for targeted interventions beyond traditional antimicrobial strategies. For this Special Issue, we welcome contributions that will advance our fundamental understanding of the oral microbiota’s composition, function, and host interactions across health and disease states. We particularly encourage submissions exploring novel molecular mechanisms, diagnostic approaches, and therapeutic strategies targeting the oral microbiome.
Potential topics include, but are not limited to, the following:
- Molecular mechanisms underlying host–microbiome interactions in oral health and disease;
- Advanced multi-omics approaches to characterizing oral microbial communities;
- Novel biomarkers derived from the oral microbiota for disease prediction and monitoring;
- Innovative antimicrobial strategies with enhanced specificity for oral pathogens;
- Probiotics, prebiotics, and postbiotics in oral health maintenance;
- The role of the oral microbiota in modulating local and systemic inflammation;
- Microbiome considerations in special patient populations (immunocompromised, elderly, pediatric);
- Technological advances in the sampling, analysis, and manipulation of oral microbial communities.
We invite researchers and clinicians to contribute original research articles, comprehensive reviews, systematic analyses, and clinical studies that will collectively advance our understanding of the oral microbiota's role in health and disease.
Dr. Biagio Rapone
Guest Editor
Manuscript Submission Information
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Keywords
- oral microbiome
- periodontal health and disease
- host-microbiome interactions
- oral pathogens
- antimicrobial strategies
- probiotics
- prebiotics
- postbiotics
- ioactive metabolites
- immunocompromised
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