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Polymers as Carriers of Active Heterocyclic Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Materials Science".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 282

Special Issue Editor


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Guest Editor
Laboratory of Nanomaterials and Nanotechnology, Faculty of Food Technology, University of Agriculture, ul. Balicka 122, 30-149 Kraków, Poland
Interests: composites; polysaccharide; biopolymers; nanomaterials; nanoparticles; organic synthesis; synthesis; materials chemistry; material characterization; nanomaterials synthesis; nanoparticle synthesis; nanoparticle preparation; quantum dots; carbohydrate chemistry; starch; carbon nanotubes; metal nanoparticles; nanosilver; nanogold
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Special Issue Information

Dear Colleagues,

Heterocyclic compounds hold significant importance in biotechnology and pharmaceutics. They are crucial constituents of pharmaceutics—ubiquitous fragments in most marketed drugs. In over 80% of the most effective small-molecule drugs, there is at least one heterocyclic fragment present in their structures.

They prove to be handy tools in regulating properties like the lipophilicity, polarity, and hydrogen-bonding capacity of molecules. The incorporation of heterocycles enables drug designers to enhance the pharmacological, pharmacokinetic, toxicological, and physicochemical properties of drug candidates.

Heterocyclic systems are commonly employed as bioisosters for various functional groups in drug candidates. The strategic integration of heterocyclic groupings can optimize potency and selectivity. Their capability to engage in hydrogen bonds with target proteins further contributes to the pharmacological benefits.

Heterocycles are capable of strongly chelating metal ions. This characteristic has been utilized in the development of inhibitors for HIV-1 integrase, where the potent chelation by Mg2+ ions in the binding pocket of the enzyme is essential for its efficacy.

Heterocycles are vital constituents of natural products, including nucleic acids, amino acids, vitamins, and alkaloids. Efforts in medicinal chemistry commonly aim to replicate these natural structural motifs.

When combining heterocyclic compounds with either natural or synthetic polymers, it enables the controlled delivery of the aforementioned compounds. Heterocyclic systems may be attached to polymers via chemical bonds (covalent or coordination), hydrogen bonding, or encapsulation in nano- or micro-spherical structures (capsules, liposomes, micelles). By encapsulating heterocyclic compounds in spherical structures, hydrophilic or hydrophobic properties can be modified and solubility and stability can be improved.

Prof. Dr. Karen Khachatryan
Guest Editor

Manuscript Submission Information

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Keywords

  • heterocyclic compounds
  • polymers
  • heterocycles
  • medicinal chemistry
  • drug candidates

Published Papers

This special issue is now open for submission.
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