Immunological Avalanches: Understanding Immune System Instability in Lupus, IgA Nephropathy, and Transplant Rejection
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".
Deadline for manuscript submissions: 30 November 2025
Special Issue Editors
Interests: nephrology; chaotic systems
Special Issues, Collections and Topics in MDPI journals
Interests: renal immunopathology
Special Issue Information
Dear Colleagues,
Immune dysregulation underlies a spectrum of renal pathologies—most notably, systemic lupus erythematosus (SLE), IgA nephropathy (IgAN), and immune‐mediated allograft rejection—where a tipping point of self‐amplifying inflammatory cascades (“immunological avalanches”) precipitates irreversible kidney injury. In each context, a loss of tolerance, dysregulated complement activation, and a breach of tissue‐specific immunoregulatory checkpoints conspire to amplify effector pathways. This Special Issue delineates the common and divergent molecular triggers, effector mechanisms, and potential therapeutic nodes across lupus nephritis, mesangial IgA deposition, and transplant rejection, with a specific focus on early biomarkers and precision‐guided immunomodulation.
This Special Issue aims to amalgamate the current understanding of the mechanisms by which immune homeostasis collapses into runaway inflammation in SLE, IgA nephropathy, and renal allograft rejection, as well as highlighting translational strategies to detect, intercept, and therapeutically modulate these immunological avalanches. The discovery and characterization of new therapeutic targets and strategies, including immunological avalanches, is the main topic of the Biomedicines journal.
In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: A) pathogenic triggers; B) effector cascades, e.g., complement pathways and neutrophil extracellular traps; C) biomarkers of instability, e.g., circulating complement split products (C3a and C5a), donor‐derived cell‐free DNA, and cytokine signatures; and D) therapeutic interception.
We look forward to receiving your contributions
Dr. Davide Viggiano
Dr. Giuseppe Gigliotti
Dr. Angelo Ferrantelli
Guest Editors
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Keywords
- immunological avalanche
- lupus nephritis
- IgA nephropathy
- transplant rejection
- complement dysregulation
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