Interplay Between Coagulation and Inflammation: Molecular Mechanisms, Clinical Implications, and Therapeutic Strategies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (20 June 2025) | Viewed by 1161
Special Issue Editor
Interests: endothelial inflammation; endothelial permeability; vascular remodeling
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The common factor underlying many illnesses affecting the cardiovascular system is the interaction between inflammation and coagulation. Under normal circumstances, the equilibrium between anticoagulants and coagulants and anti-inflammatory and inflammatory pathways preserves homeostasis. In a diseased state, the body’s response to infection or injury leads to the activation of the coagulation and inflammation cascade, commonly referred to as immunothrombosis. However, excessive and unregulated immunothrombosis responses cause catastrophic damage that compromises organ functions, also known as thromboinflammation. Thromboinflammation is especially relevant to COVID-19 since the virus causes enhanced inflammation and coagulation responses in infected patients. The natural anticoagulants such as thrombomodulin, anti-thrombin, and activated protein C facilitate the neutralization of some inflammatory mediators and increase the endothelial barrier function. Hence, the downregulation of anticoagulant pathways not only promotes thrombosis but also amplifies the inflammatory process. Thus, elucidating the role of inflammation in coagulation and vice versa will introduce new perspectives to improve clinical diagnostics and therapeutic strategies for the future, leading to improved patient care.
We welcome original research articles, reviews, or shorter perspective articles on all aspects related to the coagulation and inflammation processes. Articles with mechanistic insights from cellular and molecular perspectives are especially welcome. Some of the relevant topics include, but are not limited to, the following: thromboinflammation in COVID-19; thromboinflammation and oxidative stress; thromboinflammation and aging; the role of extracellular vesicle biology in thromboinflammation; thromboinflammation affecting the cognitive functions of brain and visual acuity; and thromboinflammation affecting vascular and tissue remodeling.
Dr. Hemant Giri
Guest Editor
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Keywords
- coagulation
- inflammation
- endothelial dysfunction
- anticoagulants
- inflammation
- venous thrombosis
- venous thromboembolism
- thromboinflammation
- coagulation
- inflammasomes
- neutrophil extracellular traps
- platelets
- endothelial activation
- vascular remodeling
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