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The Interaction between Sleep Disorders and Mental Diseases

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 4523

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Special Issue Editors

Dr. Agata Gabryelska

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Guest Editor

Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-151 Lodz, Poland
Interests: sleep; obstructive sleep apnea; insomnia; affective disorders; circadian rhythm
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Dominik Strzelecki

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Guest Editor

Department of Affective and Psychotic Disorders, Medical University of Lodz, 92-216 Lodz, Poland
Interests: schizophrenia; affective disorders; anxiety disorders; personality disorders; psychopharmacology
Special Issues, Collections and Topics in MDPI journals

Dr. Marcin Sochal

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Guest Editor

Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 90-419 Lodz, Poland
Interests: sleep; sleep deprivation; insomnia; psychoneuroimmunology; psychiatric disorders
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The prevalence of sleep disorders has greatly increased in recent decades. Benzodiazepines are the third most overprescribed drugs, highlighting this problem. Sleep strongly contributes to an individual’s general health, and thus sleep disorders can contribute to multiple comorbidities, such as issues with cardiovascular, metabolic, immunological and mental health. The last group has a particular relationship with sleep, with mental health and sleep bi-directionally affecting each other with significant intertwining. Furthermore, sleep disturbances often present as one of the first symptoms of most psychiatric diseases, making them a challenge in both diagnosis and treatment.

In this Special Issue, we invite original and review papers on the topics of sleep disorders, mental diseases, and their interaction on a molecular level. We encourage contributions to this Special Issue of the International Journal of Molecular Sciences evaluating physiology, pathophysiology, diagnostic and treatment processes, as well as comorbidities that are a result of the interaction between sleep disorders and mental diseases.

Dr. Agata Gabryelska
Prof. Dr. Dominik Strzelecki
Dr. Marcin Sochal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

sleep disorders
mental diseases
psychiatric diseases
affective disorders
insomnia

Published Papers (3 papers)

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Research

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9 pages, 586 KiB

Open AccessCommunication

Evaluation of the Continuous Positive Airway Pressure Effect on Neurotrophins’ Gene Expression and Protein Levels

by Agata Gabryelska, Szymon Turkiewicz, Marta Ditmer, Adrian Gajewski, Piotr Białasiewicz, Dominik Strzelecki, Maciej Chałubiński and Marcin Sochal

Int. J. Mol. Sci. 2023, 24(23), 16599; https://doi.org/10.3390/ijms242316599 - 22 Nov 2023

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Abstract

Neurotrophins (NT) might be associated with the pathophysiology of obstructive sleep apnea (OSA) due to concurrent intermittent hypoxia and sleep fragmentation. Such a relationship could have implications for the health and overall well-being of patients; however, the literature on this subject is sparse. This study investigated the alterations in the serum protein concentration and the mRNA expression of the brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), neurotrophin-3 (NTF3), and neurotrophin-4 (NTF4) proteins following a single night of continuous positive airway pressure (CPAP) therapy. This study group consisted of 30 patients with OSA. Venous blood was collected twice after a diagnostic polysomnography (PSG) and PSG with CPAP treatment. Gene expression was assessed with a quantitative real-time polymerase chain reaction. An enzyme-linked immunosorbent assay was used to determine the protein concentrations. After CPAP treatment, BDNF, proBDNF, GDNF, and NTF4 protein levels decreased (p = 0.002, p = 0.003, p = 0.047, and p = 0.009, respectively), while NTF3 increased (p = 0.001). Sleep latency was correlated with ΔPSG + CPAP/PSG gene expression for BDNF (R = 0.387, p = 0.038), NTF3 (R = 0.440, p = 0.019), and NTF4 (R = 0.424, p = 0.025). OSA severity parameters were not associated with protein levels or gene expressions. CPAP therapy could have an impact on the posttranscriptional stages of NT synthesis. The expression of different NTs appears to be connected with sleep architecture but not with OSA severity. Full article

(This article belongs to the Special Issue The Interaction between Sleep Disorders and Mental Diseases)

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Review

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23 pages, 1615 KiB

Open AccessReview

The Role of the Circadian Rhythm in Dyslipidaemia and Vascular Inflammation Leading to Atherosclerosis

by Balazs Csoma and Andras Bikov

Int. J. Mol. Sci. 2023, 24(18), 14145; https://doi.org/10.3390/ijms241814145 - 15 Sep 2023

Cited by 4 | Viewed by 1869

Abstract

Cardiovascular diseases (CVD) are among the leading causes of death worldwide. Many lines of evidence suggest that the disturbances in circadian rhythm are responsible for the development of CVDs; however, circadian misalignment is not yet a treatable trait in clinical practice. The circadian rhythm is controlled by the central clock located in the suprachiasmatic nucleus and clock genes (molecular clock) located in all cells. Dyslipidaemia and vascular inflammation are two hallmarks of atherosclerosis and numerous experimental studies conclude that they are under direct influence by both central and molecular clocks. This review will summarise the results of experimental studies on lipid metabolism, vascular inflammation and circadian rhythm, and translate them into the pathophysiology of atherosclerosis and cardiovascular disease. We discuss the effect of time-respected administration of medications in cardiovascular medicine. We review the evidence on the effect of bright light and melatonin on cardiovascular health, lipid metabolism and vascular inflammation. Finally, we suggest an agenda for future research and recommend on clinical practice. Full article

(This article belongs to the Special Issue The Interaction between Sleep Disorders and Mental Diseases)

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17 pages, 1276 KiB

Open AccessReview

Does EGFR Signaling Mediate Orexin System Activity in Sleep Initiation?

by Marina Kniazkina and Vyacheslav Dyachuk

Int. J. Mol. Sci. 2023, 24(11), 9505; https://doi.org/10.3390/ijms24119505 - 30 May 2023

Viewed by 1530

Abstract

Sleep–wake cycle disorders are an important symptom of many neurological diseases, including Parkinson’s disease, Alzheimer’s disease, and multiple sclerosis. Circadian rhythms and sleep–wake cycles play a key role in maintaining the health of organisms. To date, these processes are still poorly understood and, therefore, need more detailed elucidation. The sleep process has been extensively studied in vertebrates, such as mammals and, to a lesser extent, in invertebrates. A complex, multi-step interaction of homeostatic processes and neurotransmitters provides the sleep–wake cycle. Many other regulatory molecules are also involved in the cycle regulation, but their functions remain largely unclear. One of these signaling systems is epidermal growth factor receptor (EGFR), which regulates the activity of neurons in the modulation of the sleep–wake cycle in vertebrates. We have evaluated the possible role of the EGFR signaling pathway in the molecular regulation of sleep. Understanding the molecular mechanisms that underlie sleep–wake regulation will provide critical insight into the fundamental regulatory functions of the brain. New findings of sleep-regulatory pathways may provide new drug targets and approaches for the treatment of sleep-related diseases. Full article

(This article belongs to the Special Issue The Interaction between Sleep Disorders and Mental Diseases)

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