Lipoprotein Metabolism in Health and Disease

Dear Colleagues,

Lipid homeostasis represents the coordination and regulation of numerous complex processes that work to ensure a balance between lipid influx and efflux in order to maintain the optimal lipid status required for normal cell function. As the vehicles that provide the means to deliver and transport both cholesterol and fatty acids as energy substrates to different tissues, lipoproteins are key in maintaining this balance. Lipoprotein metabolism relies on a number of enzymes, transfer proteins, apolipoproteins, and receptors to ensure the delivery and transport of lipids to different tissues. The imbalance or deregulation of lipid homeostasis can manifest as different forms of dyslipidemias, which can contribute or serve as markers of the physiopathology of a number of diseases, including cardiovascular and metabolic diseases, as well as neurodegenerative diseases such as Alzheimer’s disease. Despite the advances in the field of lipoprotein metabolism in the past few decades, the causal relationship between lipoproteins and these different pathologies remains under active investigation.

The aim of this Special Issue is to highlight new discoveries and present up-to-date reviews in order to further enrich our understanding of the role of lipoprotein metabolism in different physiopathologies ranging from cardiovascular and metabolic to neurodegenerative diseases, and that identify innovative strategies or therapeutics for the prevention or treatment of these pathologies.

Original articles or focused reviews addressing these topics will be considered for publication.

Dr. Frances T. Yen
Guest Editor

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