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Health, Disease, and Chronobiology: Molecular and Genetics Aspects

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (20 January 2025) | Viewed by 4183

Special Issue Editors


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Guest Editor
1. Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, 46010 Valencia, Spain
2. CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28029 Madrid, Spain
Interests: precision nutrition; omics; Mediterranean diet; lifestyle; cardiovascular disease; obesity; nutrigenomics; epigenomics; metabolomics; transcriptomic; gene–diet interaction
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, 46010 Valencia, Spain
2. CIBER Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, 28029 Madrid, Spain
3. Sleep Center of Excellence, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA
4. Division of General Medicine, Department of Medicine, Columbia University Irving Medical Center, New York, NY 10032, USA
Interests: obesity; cardiovascular disease; mediterranean diet; nutrigenetic; nutrigenomic; sleep deprivation; circadian rhythms; taste perception; aging
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The daily fluctuations observed in numerous physiologic features are together referred to as circadian rhythm. Chronobiology is the study of biological rhythms and the organization of biological time. The circadian clock consists of transcriptional feedback loops between clock genes that regulate variations in functionally relevant genes in nearly all human cells. The disruption of the circadian clock is a risk factor for several diseases including cardiovascular disorders, diabetes, obesity, metabolic syndrome, neurological diseases, and cancer, among others.  Every day, the study of chronobiological features of lifestyle and health receives greater emphasis. Currently, it has been demonstrated that there is a significant association between chronotype and an increased risk of depression and cardiometabolic disorders. To better comprehend the molecular and cellular bases of these connections, however, additional mechanistic research is required in both human and animal models. 

With this Special Issue, we hope to collect both original contributions and review papers focusing on the analysis of the genome, epigenome, transcriptome, microbiome, transcriptome, and omics integration in relation to chronobiological aspects of health and disease.

Prof. Dr. Dolores Corella
Dr. Rocío Barragán
Guest Editors

Manuscript Submission Information

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Keywords

  • chronobiology
  • timing of food
  • sleep
  • time-restricted eating
  • metabolism
  • genomics
  • epigenomics
  • metabolomics
  • microbiome
  • mechanisms

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Published Papers (2 papers)

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Research

24 pages, 11143 KiB  
Article
Unraveling the Mysteries of Sleep: Exploring Phylogenomic Sleep Signals in the Recently Characterized Archaeal Phylum Lokiarchaeota near Loki’s Castle
by Seithikurippu R. Pandi-Perumal, Konda Mani Saravanan, Sayan Paul, David Warren Spence and Saravana Babu Chidambaram
Int. J. Mol. Sci. 2025, 26(1), 60; https://doi.org/10.3390/ijms26010060 - 25 Dec 2024
Cited by 1 | Viewed by 944
Abstract
Sleep is a universally conserved behavior whose origin and evolutionary purpose are uncertain. Using phylogenomics, this article investigates the evolutionary foundations of sleep from a never before used perspective. More specifically, it identifies orthologs of human sleep-related genes in the Lokiarchaeota of the [...] Read more.
Sleep is a universally conserved behavior whose origin and evolutionary purpose are uncertain. Using phylogenomics, this article investigates the evolutionary foundations of sleep from a never before used perspective. More specifically, it identifies orthologs of human sleep-related genes in the Lokiarchaeota of the Asgard superphylum and examines their functional role. Our findings indicate that a conserved suite of genes associated with energy metabolism and cellular repair is involved, thus suggesting that sleep plays a primordial role in cellular maintenance. The data cited lend credence to the idea that sleep improves organismal fitness across evolutionary time by acting as a restorative process. Notably, our approach demonstrates that phylogenomics is more useful than standard phylogenetics for clarifying common evolutionary traits. By offering insight into the evolutionary history of sleep and putting forth a novel model framework for sleep research across taxa, these findings contribute to our growing understanding of the molecular foundation of sleep. This study lays the groundwork for further investigations into the importance of sleep in various organisms. Such investigations could have consequences for improving human health and more generally could provide a deeper comprehension of the fundamental processes of life. Full article
(This article belongs to the Special Issue Health, Disease, and Chronobiology: Molecular and Genetics Aspects)
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15 pages, 6047 KiB  
Article
Systemic Inflammation Disrupts Circadian Rhythms and Diurnal Neuroimmune Dynamics
by Wai-Yin Cheng, Po-Lam Chan, Hang-Yin Ong, Ka-Hing Wong and Raymond Chuen-Chung Chang
Int. J. Mol. Sci. 2024, 25(13), 7458; https://doi.org/10.3390/ijms25137458 - 7 Jul 2024
Cited by 4 | Viewed by 2210
Abstract
Circadian rhythms regulate physiological processes in approximately 24 h cycles, and their disruption is associated with various diseases. Inflammation may perturb circadian rhythms, though these interactions remain unclear. This study examined whether systemic inflammation induced by an intraperitoneal injection of lipopolysaccharide (LPS) could [...] Read more.
Circadian rhythms regulate physiological processes in approximately 24 h cycles, and their disruption is associated with various diseases. Inflammation may perturb circadian rhythms, though these interactions remain unclear. This study examined whether systemic inflammation induced by an intraperitoneal injection of lipopolysaccharide (LPS) could alter central and peripheral circadian rhythms and diurnal neuroimmune dynamics. Mice were randomly assigned to two groups: the saline control group and the LPS group. The diurnal expression of circadian clock genes and inflammatory cytokines were measured in the hypothalamus, hippocampus, and liver. Diurnal dynamic behaviors of microglia were also assessed. Our results revealed that the LPS perturbed circadian gene oscillations in the hypothalamus, hippocampus, and liver. Furthermore, systemic inflammation induced by the LPS could trigger neuroinflammation and perturb the diurnal dynamic behavior of microglia in the hippocampus. These findings shed light on the intricate link between inflammation and circadian disruption, underscoring their significance in relation to neurodegenerative diseases. Full article
(This article belongs to the Special Issue Health, Disease, and Chronobiology: Molecular and Genetics Aspects)
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