Special Issue "Glioblastoma – Pathogenesis, Cellular and Molecular Mechanism"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 December 2020).
Glioblastoma (GBM) is the most frequent and aggressive primary adult brain tumor with about 5% survival rate at 5 years. Even with the current multimodal therapy, including targeted and anti-angiogenetic therapy, the mean survival of GBM patients is still approximately 15 months. Because of its extremely unfavorable prognosis, it is imperative to investigate new possible altered molecular mechanisms involved in the GBM pathogenesis that can translate in the development of a more effective therapeutic strategies for this cancer. This Special Issue of the International Journal of Molecular Sciences, entitled “Glioblastoma – Pathogenesis, Cellular and Molecular Mechanism” will focus on how intracellular molecular pathways are altered in tumor cells. Authors are invited to submit manuscripts that analyze molecular mechanisms possibly involved in GBM pathogenesis, such as cancer stem cells, apoptosis and autophagia, kinome, cell cycle and metabolism, angiogenesis, lncRNA, miRNA and RNA editing pathways. The results from these studies may provide useful information in devising treatments that may enhance survival rates of GBM patients.
Dr. Maurizio Martini
Manuscript Submission Information
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- Cancer stem cells
- Kinase pathways
- Tumor suppressor genes
- lnRNA, miRNA
- RNA editing mechanism