Calcium Signaling in Health and Diseases

Dear Colleagues, 

The last few years have seen huge development in the field of calcium signaling, from the improvement of calcium probes that are now tailored and targeted to monitor subcellular calcium changes at almost any resolution to the development of modern technologies for calcium imaging or the identification of critically important molecular players involved in calcium transport and homeostasis. These new tools are allowing the discovery of new insights regarding calcium signaling and most importantly how changes in calcium signaling may contribute to the development of a number of diseases. For instance, the discovery of the molecular machinery involved in store-operated Ca²⁺ entry, the release of Ca²⁺ from intracellular stores at the ER and its modulation by BCl2, or Ca²⁺ transfer from the ER to mitochondria via the mitochondrial Ca²⁺ uniporter may contribute to different pathological situations such as cancer, defective immune responses, and neurodegenerative diseases, among many others. The involvement of calcium dishomeostasis in many different pathological situations is under intense scrutiny in laboratories around the world. The development of new applications for established modulators of calcium fluxes and the de novo synthesis of new drugs may help to accelerate new treatments for old diseases. The present issue is intended to showcase the state of the art of calcium signaling in health and disease with the aim of promoting even further research into calcium for unmet disease diagnostics, prognosis, or treatment.

Dr. Carlos Villalobos
Dr. Sendoa Tajada
Guest Editors

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