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Advances in Coagulation and Anticoagulation
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Advances in Coagulation and Anticoagulation

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 5073

Special Issue Editor

Prof. Dr. Vance G. Nielsen

E-Mail Website
Guest Editor
Department of Anesthesiology, University of Arizona College of Medicine, Tucson, AZ 85719, USA
Interests: coagulation; thrombelastography; snake venom; heme mediated regulation; heavy metals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There have been several advances in molecular and clinical venues that have dramatically changed our view of coagulation and anticoagulation in recent years. This Special Issue invites all works concerning coagulation and anticoagulation that possess molecular aspects and mechanisms. This may include the first clinical trial of new procoagulant or anticoagulant agents, as well as original descriptions of preclinical animal models that detail the pharmacokinetic and pharmacodynamic impacts of such agents. Toxic interactions of organic and inorganic molecules are also of interest, and may take the form of in silico, in vitro, and in vivo models. Original works and review articles are welcome.

Prof. Dr. Vance G. Nielsen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • coagulation
  • anticoagulation
  • procoagulant
  • anticoagulant
  • molecular mechanism

Published Papers (4 papers)

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Research

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16 pages, 1653 KiB  
Article
Unified Methodology for the Primary Preclinical In Vivo Screening of New Anticoagulant Pharmaceutical Agents from Hematophagous Organisms
by Maria A. Kostromina, Elena A. Tukhovskaya, Elvira R. Shaykhutdinova, Yuliya A. Palikova, Viktor A. Palikov, Gulsara A. Slashcheva, Alina M. Ismailova, Irina N. Kravchenko, Igor A. Dyachenko, Evgeniy A. Zayats, Yuliya A. Abramchik, Arkady N. Murashev and Roman S. Esipov
Int. J. Mol. Sci. 2024, 25(7), 3986; https://doi.org/10.3390/ijms25073986 - 03 Apr 2024
Viewed by 370
Abstract
The development of novel anticoagulants requires a comprehensive investigational approach that is capable of characterizing different aspects of antithrombotic activity. The necessary experiments include both in vitro assays and studies on animal models. The required in vivo approaches include the assessment of pharmacokinetic [...] Read more.
The development of novel anticoagulants requires a comprehensive investigational approach that is capable of characterizing different aspects of antithrombotic activity. The necessary experiments include both in vitro assays and studies on animal models. The required in vivo approaches include the assessment of pharmacokinetic and pharmacodynamic profiles and studies of hemorrhagic and antithrombotic effects. Comparison of anticoagulants with different mechanisms of action and administration types requires unification of the experiment scheme and its adaptation to existing laboratory conditions. The rodent thrombosis models in combination with the assessment of hemostasis parameters and hematological analysis are the classic methods for conducting preclinical studies. We report an approach for the comparative study of the activity of different anticoagulants in vivo, including the investigation of pharmacodynamics and the assessment of hemorrhagic effects (tail-cut bleeding model) and pathological thrombus formation (inferior vena cava stenosis model of venous thrombosis). The reproducibility and uniformity of our set of experiments were illustrated on unfractionated heparin and dabigatran etexilate (the most common pharmaceuticals in antithrombic therapy) as comparator drugs and an experimental drug variegin from the tick Amblyomma variegatum. Variegin is notorious since it is a potential analogue of bivalirudin (Angiomax, Novartis AG, Basel, Switzerland), which is now being actively introduced into antithrombotic therapy. Full article
(This article belongs to the Special Issue Advances in Coagulation and Anticoagulation)
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12 pages, 11477 KiB  
Article
Comparative Thrombin Generation in Animal Plasma: Sensitivity to Human Factor XIa and Tissue Factor
by Yideng Liang, Ivan Tarandovskiy, Stepan S. Surov and Mikhail V. Ovanesov
Int. J. Mol. Sci. 2023, 24(16), 12920; https://doi.org/10.3390/ijms241612920 - 18 Aug 2023
Cited by 1 | Viewed by 793
Abstract
Preclinical evaluation of drugs in animals helps researchers to select potentially informative clinical laboratory markers for human trials. To assess the utility of animal thrombin generation (TG) assay, we studied the sensitivity of animal plasmas to triggers of TG, human Tissue Factor (TF), [...] Read more.
Preclinical evaluation of drugs in animals helps researchers to select potentially informative clinical laboratory markers for human trials. To assess the utility of animal thrombin generation (TG) assay, we studied the sensitivity of animal plasmas to triggers of TG, human Tissue Factor (TF), and Activated Factor XI (FXIa). Pooled human, mouse, rat, guinea pig, rabbit, bovine, sheep, and goat plasmas were used in this study. TF- or FXIa-triggered TG and clotting were measured via fluorescence and optical density, respectively. Thrombin peak height (TPH) and time (TPT), clot time (CT), and fibrin clot density (FCD) were all analyzed. The trigger low and high sensitivity borders (LSB and HSB) for each assay parameter were defined as TF and FXIa concentrations, providing 20 and 80% of the maximal parameter value, unless the baseline (no trigger) value exceeded 20% of the maximal, in which case, LSB was derived from 120% of baseline value. Normal human samples demonstrated lower TPH HSB than most of the animal samples for both TF and FXIa. Animal samples, except mice, demonstrated lower TPT LSB for FXIa versus humans. Most rodent and rabbit samples produced baseline TG in the absence of TG triggers that were consistent with the pre-activation of blood coagulation. FCD was not sensitive to both TF and FXIa in either of the plasmas. Animal plasmas have widely variable sensitivities to human TF and FXIa, which suggests that optimization of trigger concentration is required prior to test use, and this complicates the extrapolation of animal model results to humans. Full article
(This article belongs to the Special Issue Advances in Coagulation and Anticoagulation)
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Review

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23 pages, 1531 KiB  
Review
Factor VII Activating Protease (FSAP) and Its Importance in Hemostasis—Part I: FSAP Structure, Synthesis and Activity Regulation: A Narrative Review
by Iga Kwiatkowska, Ewa Żekanowska, Simona Lattanzi, Andrea M. Alexandre, Agata Kister-Kowalska and Artur Słomka
Int. J. Mol. Sci. 2023, 24(6), 5473; https://doi.org/10.3390/ijms24065473 - 13 Mar 2023
Cited by 1 | Viewed by 1218
Abstract
Factor VII activating protease (FSAP) was first isolated from human plasma less than 30 years ago. Since then, many research groups have described the biological properties of this protease and its role in hemostasis and other processes in humans and other animals. With [...] Read more.
Factor VII activating protease (FSAP) was first isolated from human plasma less than 30 years ago. Since then, many research groups have described the biological properties of this protease and its role in hemostasis and other processes in humans and other animals. With the progress of knowledge about the structure of FSAP, several of its relationships with other proteins or chemical compounds that may modulate its activity have been explained. These mutual axes are described in the present narrative review. The first part of our series of manuscripts on FSAP describes the structure of this protein and the processes leading to the enhancement and inhibition of its activities. The following parts, II and III, concern the role of FSAP in hemostasis and in the pathophysiology of human diseases, with particular emphasis on cardiovascular diseases. Full article
(This article belongs to the Special Issue Advances in Coagulation and Anticoagulation)
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21 pages, 1760 KiB  
Review
The Gilded Clot: Review of Metal-Modulated Platelet Activation, Coagulation, and Fibrinolysis
by Vance G. Nielsen, Tanner Goff, Brent D. Hunsaker and Coulter D. Neves
Int. J. Mol. Sci. 2023, 24(4), 3302; https://doi.org/10.3390/ijms24043302 - 07 Feb 2023
Cited by 4 | Viewed by 2027
Abstract
The processes of blood coagulation and fibrinolysis that in part maintain the physical integrity of the circulatory system and fluidity of its contents are complex as they are critical for life. While the roles played by cellular components and circulating proteins in coagulation [...] Read more.
The processes of blood coagulation and fibrinolysis that in part maintain the physical integrity of the circulatory system and fluidity of its contents are complex as they are critical for life. While the roles played by cellular components and circulating proteins in coagulation and fibrinolysis are widely acknowledged, the impact of metals on these processes is at best underappreciated. In this narrative review we identify twenty-five metals that can modulate the activity of platelets, plasmatic coagulation, and fibrinolysis as determined by in vitro and in vivo investigations involving several species besides human beings. When possible, the molecular interactions of the various metals with key cells and proteins of the hemostatic system were identified and displayed in detail. It is our intention that this work serve not as an ending point, but rather as a fair evaluation of what mechanisms concerning metal interactions with the hemostatic system have been elucidated, and as a beacon to guide future investigation. Full article
(This article belongs to the Special Issue Advances in Coagulation and Anticoagulation)
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