Antivenom Development with Non-biological Agents and Approaches
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Toxicology".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2196
Special Issue Editor
Interests: coagulation; thrombelastography; snake venom; heme mediated regulation; heavy metals
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Envenomation by snakes is a global issue, resulting in significant morbidity and mortality in millions of people annually. While traditional antivenom treatment is available in developed countries, there is a large unmet need for such therapy worldwide. Lastly, not all snake venoms have antivenoms manufactured due to rairity of the snake or economic state of the environment where envenomation occurs.
Of interest, the concept of antivenoms that are not snake species specific, but instead are venom enzyme specific has lead to promising new antivenoms that are inorganic or not antibody based to emerge. Such compounds include specific phospholipase A2 inhibitors, ruthenium containing compounds, and various gold and silver nanoparticles. Also of interest, the diversification of delivery of such antivenoms may be critical, with both site-directed (e.g., administration into the bite site) and systemic treatment possible. This special issue invites submissions of manuscripts describing the composition, mechanisms of action, and efficacy of this new class of antivenoms. The submissions may be original works that describe in vitro, in vivo, or in silico interactions of the antivenoms with venoms or venom enzymes. Reviews of such antivenoms are also welcome.
Prof. Dr. Vance G. Nielsen
Guest Editor
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Keywords
- snake venom
- antivenom
- inorganic compounds
- chelators
- ruthenium
- gold nanoparticles
- silver nanoparticles
- metalloproteinase inhibitors
- serine protease inhibitors
- phospholipase A2 inhibitors
- neurotoxins
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